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Mefv MEFV, pyrin innate immunity regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 58923, updated on 22-Apr-2017
Official Symbol
Mefvprovided by RGD
Official Full Name
MEFV, pyrin innate immunity regulatorprovided by RGD
Primary source
RGD:61889
See related
Ensembl:ENSRNOG00000008134
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
pyrin
Orthologs
Location:
10q12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12045813..12056229)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (10804440..10813964)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551940 Neighboring gene zinc finger protein 263 Neighboring gene olfactory receptor 1361-like Neighboring gene olfactory receptor 1358

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NLRP3 inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage inflammatory protein 1 alpha production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage inflammatory protein 1 alpha production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to silicon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
autophagosome IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
microtubule associated complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pyrin
Names
Mediterranean fever
marenostrin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031634.1NP_113822.1  pyrin

    See identical proteins and their annotated locations for NP_113822.1

    Status: PROVISIONAL

    Source sequence(s)
    AF143410
    UniProtKB/Swiss-Prot
    Q9JJ25
    Related
    ENSRNOP00000011073.4, ENSRNOT00000011073.5
    Conserved Domains (2) summary
    cd00021
    Location:443482
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam02758
    Location:2387
    PYRIN; PAAD/DAPIN/Pyrin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    12045813..12056229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597485.1XP_017452974.1  pyrin isoform X1

  2. XM_017597486.1XP_017452975.1  pyrin isoform X2

  3. XM_017597488.1XP_017452977.1  pyrin isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXG0
    Related
    ENSRNOP00000070256.1, ENSRNOT00000081191.1
  4. XM_017597487.1XP_017452976.1  pyrin isoform X3

  5. XM_017597489.1XP_017452978.1  pyrin isoform X5

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    10738861..10748385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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