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Casp9 caspase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58918, updated on 18-Sep-2024

Summary

Official Symbol
Casp9provided by RGD
Official Full Name
caspase 9provided by RGD
Primary source
RGD:61867
See related
EnsemblRapid:ENSRNOG00000012944 AllianceGenome:RGD:61867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mch6; Apaf3; Casp9_v1; Ice-Lap6; Casp-9-CTD
Summary
Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Located in cytosol; mitochondrion; and nucleus. Used to study pre-malignant neoplasm. Biomarker of several diseases, including cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); neurodegenerative disease (multiple); and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 70.4), Adrenal (RPKM 66.9) and 9 other tissues See more
Orthologs
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Genomic context

See Casp9 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159391907..159410341)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (154108872..154126628)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (160356211..160373774)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DNA damage inducible 1 homolog 2 Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene chymotrypsin like elastase 2A Neighboring gene chymotrypsin C Neighboring gene uncharacterized LOC120103027 Neighboring gene EF-hand domain family, member D2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables death domain binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glial cell apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in leukocyte apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of apoptosome ISO
Inferred from Sequence Orthology
more info
 
part_of caspase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase-9
Names
25 kDa caspase-9 dominant negative protein
Ice-like apoptotic protease 6
apoptotic protease Mch-6
apoptotic protease activating factor 3
caspase 9, apoptosis-related cysteine peptidase
caspase-9 dominant negative form
caspase-9-carboxyl-terminal divergent
NP_113820.1
XP_038966621.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429871.1NP_001416800.1  caspase-9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
  2. NM_031632.3NP_113820.1  caspase-9 isoform 1

    See identical proteins and their annotated locations for NP_113820.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y7W8, A6ITW3, F1M776, Q9JHK1
    Related
    ENSRNOP00000017972.5, ENSRNOT00000017972.8
    Conserved Domains (2) summary
    cd08326
    Location:1990
    CARD_CASP9; Caspase activation and recruitment domain of Caspase-9
    cd00032
    Location:190452
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    159391907..159410341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110693.2XP_038966621.1  caspase-9 isoform X1

    Conserved Domains (1) summary
    cd00032
    Location:74336
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...