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Tdh L-threonine dehydrogenase [ Mus musculus (house mouse) ]

Gene ID: 58865, updated on 26-Sep-2022

Summary

Official Symbol
Tdhprovided by MGI
Official Full Name
L-threonine dehydrogenaseprovided by MGI
Primary source
MGI:MGI:1926231
See related
Ensembl:ENSMUSG00000021953 AllianceGenome:MGI:1926231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables L-threonine 3-dehydrogenase activity and identical protein binding activity. Acts upstream of or within threonine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; tail mesenchyme; and yolk sac endoderm. Orthologous to human TDH (L-threonine dehydrogenase (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 17.3), stomach adult (RPKM 0.9) and 1 other tissue See more
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Genomic context

See Tdh in Genome Data Viewer
Location:
14; 14 D1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63729796..63746541, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63492347..63509092, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36165 Neighboring gene B lymphoid kinase Neighboring gene family with sequence similarity 167, member A Neighboring gene predicted gene 17232 Neighboring gene myotubularin related protein 9 Neighboring gene VISTA enhancer mm1542

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-threonine 3-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-threonine 3-dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within threonine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in threonine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
L-threonine 3-dehydrogenase, mitochondrial
NP_067455.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021480.5NP_067455.5  L-threonine 3-dehydrogenase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_067455.5

    Status: VALIDATED

    Source sequence(s)
    AK077571, BC058860
    Consensus CDS
    CCDS27202.1
    UniProtKB/Swiss-Prot
    Q8K3F7, Q9JLU3
    Related
    ENSMUSP00000022522.9, ENSMUST00000022522.15
    Conserved Domains (2) summary
    cd05272
    Location:57363
    TDH_SDR_e; L-threonine dehydrogenase, extended (e) SDRs
    COG0451
    Location:84363
    WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    63729796..63746541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)