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Cysltr1 cysteinyl leukotriene receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 58861, updated on 9-Mar-2023

Summary

Official Symbol
Cysltr1provided by MGI
Official Full Name
cysteinyl leukotriene receptor 1provided by MGI
Primary source
MGI:MGI:1926218
See related
Ensembl:ENSMUSG00000052821 AllianceGenome:MGI:1926218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyslt1; CysLT1R
Summary
Enables leukotriene receptor activity. Acts upstream of or within several processes, including calcium ion transport; chemotaxis; and inflammatory response to antigenic stimulus. Is integral component of plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 1.9), bladder adult (RPKM 1.0) and 18 other tissues See more
Orthologs
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Genomic context

See Cysltr1 in Genome Data Viewer
Location:
X; X D
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105617952..105647329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106576509..106603679, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C1 pseudogene Neighboring gene fibronectin type III domain containing 3C1 Neighboring gene predicted gene, 24622 Neighboring gene predicted gene 5127 Neighboring gene predicted gene 14877 Neighboring gene zinc finger protein 277 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteinyl leukotriene receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables leukotriene receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables leukotriene receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cysteinyl leukotriene receptor 1
Names
LTD4 receptor
cysteinyl leukotriene D4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281859.1NP_001268788.1  cysteinyl leukotriene receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001268788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK033476, AL732460
    Consensus CDS
    CCDS41098.1
    UniProtKB/Swiss-Prot
    Q99JA4, Q9JK47
    UniProtKB/TrEMBL
    A0A8C6GSE3
    Related
    ENSMUSP00000063520.4, ENSMUST00000064892.4
    Conserved Domains (2) summary
    pfam00001
    Location:55310
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:47264
    7tm_4; Olfactory receptor
  2. NM_001281862.1NP_001268791.1  cysteinyl leukotriene receptor 1 isoform b

    See identical proteins and their annotated locations for NP_001268791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL732460
    UniProtKB/Swiss-Prot
    Q99JA4
    Conserved Domains (1) summary
    cd15158
    Location:26308
    7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_021476.5NP_067451.2  cysteinyl leukotriene receptor 1 isoform a

    See identical proteins and their annotated locations for NP_067451.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK033476, AL732460
    Consensus CDS
    CCDS41098.1
    UniProtKB/Swiss-Prot
    Q99JA4, Q9JK47
    UniProtKB/TrEMBL
    A0A8C6GSE3
    Related
    ENSMUSP00000109108.2, ENSMUST00000113480.2
    Conserved Domains (2) summary
    pfam00001
    Location:55310
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:47264
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105617952..105647329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162055.1XP_036017948.1  cysteinyl leukotriene receptor 1 isoform X1

    Conserved Domains (1) summary
    cd15158
    Location:26308
    7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors