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Psmb4 proteasome 20S subunit beta 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58854, updated on 5-Mar-2024

Summary

Official Symbol
Psmb4provided by RGD
Official Full Name
proteasome 20S subunit beta 4provided by RGD
Primary source
RGD:61877
See related
AllianceGenome:RGD:61877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in negative regulation of inflammatory response to antigenic stimulus and proteasomal protein catabolic process. Predicted to be located in ciliary basal body; mitochondrion; and nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in nucleus. Orthologous to human PSMB4 (proteasome 20S subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1319.9), Thymus (RPKM 1188.4) and 9 other tissues See more
Orthologs
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Genomic context

See Psmb4 in Genome Data Viewer
Location:
2q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185131787..185134561, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182442757..182445532, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196043546..196046320, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5, pseudogene 2 Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene high mobility group protein B1 pseudogene Neighboring gene small nucleolar RNA U89 Neighboring gene selenium binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteasome subunit beta type-4
Names
RN3
macropain beta chain
multicatalytic endopeptidase complex beta chain
proteasome (prosome, macropain) subunit, beta type 4
proteasome beta 4 subunit
proteasome beta chain
proteasome chain 3
proteasome subunit beta 4
NP_113817.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031629.2NP_113817.2  proteasome subunit beta type-4

    See identical proteins and their annotated locations for NP_113817.2

    Status: VALIDATED

    Source sequence(s)
    FQ232850
    UniProtKB/Swiss-Prot
    P28071, P34067, P97719
    UniProtKB/TrEMBL
    A6K2T2
    Conserved Domains (2) summary
    COG0638
    Location:45241
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03760
    Location:52247
    proteasome_beta_type_4; proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185131787..185134561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)