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RAD21 RAD21 cohesin complex component [ Homo sapiens (human) ]

Gene ID: 5885, updated on 5-Jul-2020

Summary

Official Symbol
RAD21provided by HGNC
Official Full Name
RAD21 cohesin complex componentprovided by HGNC
Primary source
HGNC:HGNC:9811
See related
Ensembl:ENSG00000164754 MIM:606462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGS; HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21
Summary
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 65.1), lymph node (RPKM 64.2) and 25 other tissues See more
Orthologs

Genomic context

See RAD21 in Genome Data Viewer
Location:
8q24.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (116845934..116874776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (117858173..117887105, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268030 Neighboring gene UTP23 small subunit processome component Neighboring gene RAD21 antisense RNA 1 Neighboring gene microRNA 3610 Neighboring gene uncharacterized LOC105375715 Neighboring gene alanine and arginine rich domain containing protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RAD21 homolog (S. pombe, RAD21) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr decreases the amount of Scc1/Rad21 protein in the chromatin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25655, FLJ40596, KIAA0078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination TAS
Traceable Author Statement
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
reciprocal meiotic recombination TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
chromatin IEA
Inferred from Electronic Annotation
more info
 
chromosome TAS
Traceable Author Statement
more info
 
chromosome, centromeric region TAS
Traceable Author Statement
more info
 
cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
cohesin complex TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
meiotic cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nuclear cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
double-strand-break repair protein rad21 homolog
Names
NXP-1
RAD21 homolog
SCC1 homolog
kleisin
nuclear matrix protein 1
protein involved in DNA double-strand break repair
sister chromatid cohesion 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032862.1 RefSeqGene

    Range
    5001..33933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_772

mRNA and Protein(s)

  1. NM_006265.3NP_006256.1  double-strand-break repair protein rad21 homolog

    See identical proteins and their annotated locations for NP_006256.1

    Status: REVIEWED

    Source sequence(s)
    BC050381, DA328186
    Consensus CDS
    CCDS6321.1
    UniProtKB/Swiss-Prot
    O60216
    UniProtKB/TrEMBL
    A0A024R9J0
    Related
    ENSP00000297338.2, ENST00000297338.7
    Conserved Domains (2) summary
    pfam04824
    Location:574628
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    pfam04825
    Location:1104
    Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    116845934..116874776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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