Zranb2 zinc finger RANBP2-type containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zranb2provided by RGD
Official Full Name: zinc finger RANBP2-type containing 2provided by RGD
Primary source: RGD:61854
See related: Ensembl:ENSRNOG00000009990 AllianceGenome:RGD:61854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zis; Zfp265; Znf265
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Orthologous to human ZRANB2 (zinc finger RANBP2-type containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 518.8), Brain (RPKM 471.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (249232010..249245786)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (246573110..246586942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (263864088..263877872)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that with the help of negative regulators TGF-beta and FasL, the high levels of IL-1alpha and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo.
Title: Expression of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 during sertoli cell infection by ureaplasma urealyticum.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129517 (e-PCR)
- UniSTS:212820

RH129521 (e-PCR)
- UniSTS:212820

RH136013 (e-PCR)
- UniSTS:210009

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger Ran-binding domain-containing protein 2

Names: zinc finger protein 265; zinc finger, RAN-binding domain containing 2; zinc finger, splicing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031616.2 → NP_113804.2 zinc finger Ran-binding domain-containing protein 2

Status: VALIDATED

Source sequence(s)

FM078527, FN805251, JAXUCZ010000002

UniProtKB/Swiss-Prot

A1A4C8, O35986

UniProtKB/TrEMBL

A6HWS3

Related

ENSRNOP00000107891.1, ENSRNOT00000157541.1

Conserved Domains (2) summary

smart00547
Location:67 → 91

ZnF_RBZ; Zinc finger domain

sd00029
Location:13 → 34

zf-RanBP2; RanBP2-type Zn finger [structural motif]