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Nt5e 5' nucleotidase, ecto [ Rattus norvegicus (Norway rat) ]

Gene ID: 58813, updated on 13-Jan-2019

Summary

Official Symbol
Nt5eprovided by RGD
Official Full Name
5' nucleotidase, ectoprovided by RGD
Primary source
RGD:61956
See related
Ensembl:ENSRNOG00000011071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nt5; CD73
Summary
may hydrolyze extracellular nucleotides into membrane permeable nucleosides [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 474.8), Kidney (RPKM 312.5) and 9 other tissues See more
Orthologs

Genomic context

See Nt5e in Genome Data Viewer
Location:
8q31
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (95969002..96012733)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (95464591..95508322)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene GABA(A) receptor-associated protein-like 2-like Neighboring gene uncharacterized LOC108351759 Neighboring gene myosin light polypeptide 6-like Neighboring gene sorting nexin 14 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein Neighboring gene uncharacterized LOC102554001

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC112615

Gene Ontology Provided by RGD

Function Evidence Code Pubs
5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
 
ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
AMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
AMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
adenosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
adenosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
adenosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
response to aluminum ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5'-nucleotidase
Names
5'-NT
ecto-5'-nucleotidase
NP_067587.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021576.2NP_067587.2  5'-nucleotidase precursor

    See identical proteins and their annotated locations for NP_067587.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098665
    UniProtKB/TrEMBL
    Q66HL0
    Related
    ENSRNOP00000015057.3, ENSRNOT00000015057.6
    Conserved Domains (3) summary
    COG0737
    Location:23534
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:31312
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:341509
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    95969002..96012733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    88841425..88885302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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