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Nt5e 5' nucleotidase, ecto [ Rattus norvegicus (Norway rat) ]

Gene ID: 58813, updated on 30-Sep-2021

Summary

Official Symbol
Nt5eprovided by RGD
Official Full Name
5' nucleotidase, ectoprovided by RGD
Primary source
RGD:61956
See related
EnsemblRapid:ENSRNOG00000011071
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nt5; CD73
Summary
may hydrolyze extracellular nucleotides into membrane permeable nucleosides [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 474.8), Kidney (RPKM 312.5) and 9 other tissues See more
Orthologs
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Genomic context

See Nt5e in Genome Data Viewer
Location:
8q31
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89271046..89314918)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (95969002..96012733)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15-like Neighboring gene GABA(A) receptor-associated protein-like 2-like Neighboring gene sorting nexin 14 Neighboring gene myosin light polypeptide 6-like Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC112615

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-nucleotidase activity ISO
Inferred from Sequence Orthology
more info
 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ADP catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ADP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in AMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in AMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within AMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in AMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adenosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to aluminum ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5'-nucleotidase
Names
5'-NT
ecto-5'-nucleotidase
NP_067587.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021576.2NP_067587.2  5'-nucleotidase precursor

    See identical proteins and their annotated locations for NP_067587.2

    Status: PROVISIONAL

    Source sequence(s)
    BC098665
    UniProtKB/TrEMBL
    Q66HL0
    Related
    ENSRNOP00000015057.3, ENSRNOT00000015057.7
    Conserved Domains (3) summary
    COG0737
    Location:23534
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:31312
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:341509
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    89271046..89314918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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