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Mlxipl MLX interacting protein-like [ Mus musculus (house mouse) ]

Gene ID: 58805, updated on 7-Feb-2023

Summary

Official Symbol
Mlxiplprovided by MGI
Official Full Name
MLX interacting protein-likeprovided by MGI
Primary source
MGI:MGI:1927999
See related
Ensembl:ENSMUSG00000005373 AllianceGenome:MGI:1927999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlx; ChREBP; WS-bHLH; Wbscr14; bHLHd14
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to DNA binding activity. Involved in glucose mediated signaling pathway; positive regulation of fatty acid biosynthetic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 103.3), duodenum adult (RPKM 72.0) and 13 other tissues See more
Orthologs
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Genomic context

See Mlxipl in Genome Data Viewer
Location:
5; 5 G2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135118744..135168622)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135089890..135139768)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene vacuolar protein sorting 37D Neighboring gene transducin (beta)-like 2 Neighboring gene B cell CLL/lymphoma 7B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate response element binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucose ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
carbohydrate-responsive element-binding protein
Names
MLX interacting protein-like beta
MLX interactor
Max-like protein
Williams-Beuren syndrome chromosome region 14 homolog
putative hepatic transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359237.1NP_001346166.1  carbohydrate-responsive element-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC024607, AC084109
    UniProtKB/TrEMBL
    H9U1Q1
    Conserved Domains (2) summary
    cd00083
    Location:483543
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cl28033
    Location:232479
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. NM_021455.5NP_067430.2  carbohydrate-responsive element-binding protein isoform 1

    See identical proteins and their annotated locations for NP_067430.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as zeta) encodes the longer isoform (1).
    Source sequence(s)
    AC024607
    Consensus CDS
    CCDS39316.1
    UniProtKB/Swiss-Prot
    Q99MZ3, Q9JLM5
    Related
    ENSMUSP00000005507.4, ENSMUST00000005507.10
    Conserved Domains (1) summary
    cd00083
    Location:660720
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RNA

  1. NR_152880.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as eta) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC024607, AF245476
    Related
    ENSMUST00000129008.5
  2. NR_152881.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as iota) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC024607, AF245478
    Related
    ENSMUST00000153519.8
  3. NR_152882.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as kappa) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC024607, AF245479
    Related
    ENSMUST00000128691.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135118744..135168622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504482.3XP_006504545.1  carbohydrate-responsive element-binding protein isoform X6

    See identical proteins and their annotated locations for XP_006504545.1

    Conserved Domains (2) summary
    PHA03247
    Location:192495
    PHA03247; large tegument protein UL36; Provisional
    cl00081
    Location:506621
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. XM_006504477.4XP_006504540.1  carbohydrate-responsive element-binding protein isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:369672
    PHA03247; large tegument protein UL36; Provisional
    cl00081
    Location:683798
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  3. XM_006504480.3XP_006504543.1  carbohydrate-responsive element-binding protein isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:369672
    PHA03247; large tegument protein UL36; Provisional
    cd19689
    Location:683758
    bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
  4. XM_006504478.3XP_006504541.1  carbohydrate-responsive element-binding protein isoform X2

    Conserved Domains (2) summary
    PHA03307
    Location:409656
    PHA03307; transcriptional regulator ICP4; Provisional
    cl00081
    Location:658773
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  5. XM_006504479.3XP_006504542.1  carbohydrate-responsive element-binding protein isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:308648
    PHA03247; large tegument protein UL36; Provisional
    cl00081
    Location:657772
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  6. XM_006504481.3XP_006504544.1  carbohydrate-responsive element-binding protein isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:308648
    PHA03247; large tegument protein UL36; Provisional
    cd19689
    Location:657732
    bHLHzip_MLXIPL; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins
  7. XM_030254741.1XP_030110601.1  carbohydrate-responsive element-binding protein isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:192495
    PHA03247; large tegument protein UL36; Provisional
    cl00081
    Location:506621
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RNA

  1. XR_377110.3 RNA Sequence

  2. XR_377113.4 RNA Sequence

    Related
    ENSMUST00000142385.8
  3. XR_377107.4 RNA Sequence

  4. XR_377108.4 RNA Sequence