U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cdc42ep5 CDC42 effector protein 5 [ Mus musculus (house mouse) ]

Gene ID: 58804, updated on 8-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
Cdc42ep5provided by MGI
Official Full Name
CDC42 effector protein 5provided by MGI
Primary source
MGI:MGI:1929745
See related
Ensembl:ENSMUSG00000063838 AllianceGenome:MGI:1929745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CEP5; Borg3; 1700027J19Rik; 2010007O02Rik
Summary
Predicted to enable small GTPase binding activity. Acts upstream of or within JNK cascade and Rho protein signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Mar 2025]
Expression
Biased expression in duodenum adult (RPKM 230.1), colon adult (RPKM 182.6) and 11 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cdc42ep5 in Genome Data Viewer
Location:
7 A1; 7 2.4 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4154259..4167830, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4151260..4164831, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster (LRC) member 8 Neighboring gene STARR-positive B cell enhancer ABC_E8149 Neighboring gene STARR-seq mESC enhancer starr_17920 Neighboring gene leukocyte receptor cluster (LRC) member 9 Neighboring gene calcium binding protein 39 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17921 Neighboring gene STARR-seq mESC enhancer starr_17922 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion. Farrugia AJ, et al. J Cell Biol, 2020 Sep 7. PMID 32798219, Free PMC Article
  2. Borg proteins control septin organization and are negatively regulated by Cdc42. Joberty G, et al. Nat Cell Biol, 2001 Oct. PMID 11584266
  3. A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. Hirsch DS, et al. J Biol Chem, 2001 Jan 12. PMID 11035016
  4. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Joberty G, et al. Mol Cell Biol, 1999 Oct. PMID 10490598, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
    Title: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC117885

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of pseudopodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
cdc42 effector protein 5
Names
CDC42 effector protein (Rho GTPase binding) 5
CRIB-containing BORG3 protein
binder of Rho GTPase 3
binder of Rho GTPases 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021454.4 → NP_067429.1  cdc42 effector protein 5

    See identical proteins and their annotated locations for NP_067429.1

    Status: VALIDATED

    Source sequence(s)
    AC101941
    Consensus CDS
    CCDS20733.1
    UniProtKB/Swiss-Prot
    Q3SYK1, Q9QZT9, Q9Z0X0
    Related
    ENSMUSP00000092508.5, ENSMUST00000076831.7
    Conserved Domains (2) summary
    cl00113
    Location:23 → 49
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    pfam14957
    Location:85 → 110
    BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4154259..4167830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540250.4 → XP_006540313.1  cdc42 effector protein 5 isoform X2

    See identical proteins and their annotated locations for XP_006540313.1

    UniProtKB/Swiss-Prot
    Q3SYK1, Q9QZT9, Q9Z0X0
    Conserved Domains (2) summary
    cl00113
    Location:23 → 49
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    pfam14957
    Location:85 → 110
    BORG_CEP; Cdc42 effector

  2. XM_006540249.5 → XP_006540312.1  cdc42 effector protein 5 isoform X1

    Conserved Domains (2) summary
    cl00113
    Location:32 → 58
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    pfam14957
    Location:94 → 119
    BORG_CEP; Cdc42 effector
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0X0.2 GenPept UniProtKB/Swiss-Prot:Q9Z0X0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous