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Trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Mus musculus (house mouse) ]

Gene ID: 58800, updated on 19-Mar-2023

Summary

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Official Symbol
Trpm7provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily M, member 7provided by MGI
Primary source
MGI:MGI:1929996
See related
Ensembl:ENSMUSG00000027365 AllianceGenome:MGI:1929996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
Summary
Enables calcium channel activity; cytoskeletal protein binding activity; and kinase activity. Acts upstream of or within several processes, including calcium ion transport; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Trpm7 in Genome Data Viewer
Location:
2; 2 F1
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126633478..126718181, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126791558..126876261, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene signal peptide peptidase like 2A Neighboring gene microRNA 3473g

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice. Zhong W, et al. Nat Commun, 2023 Jan 30. PMID 36717580, Free PMC Article
  2. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity. Khajavi N, et al. JCI Insight, 2023 Feb 8. PMID 36574297, Free PMC Article
  3. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies. Kim LJ, et al. J Physiol, 2022 Dec. PMID 36214387
  4. TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Rios FJ, et al. Commun Biol, 2022 Jul 26. PMID 35882956, Free PMC Article
  5. Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity. Schappe MS, et al. Nat Commun, 2022 Jun 9. PMID 35680919, Free PMC Article

See all (138) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
    Title: Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
  2. TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
    Title: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
  3. Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
    Title: Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
  4. TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
    Title: TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
  5. Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.
    Title: Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.
  6. TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt.
    Title: TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt.
  7. Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia.
    Title: Neuroprotective Effects of TRPM7 Deletion in Parvalbumin GABAergic vs. Glutamatergic Neurons following Ischemia.
  8. Mechanism of Stat1 in the neuronal Ca(2+) overload after intracerebral hemorrhage via the H3K27ac/Trpm7 axis.
    Title: Mechanism of Stat1 in the neuronal Ca(2+) overload after intracerebral hemorrhage via the H3K27ac/Trpm7 axis.
  9. Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity.
    Title: Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity.
  10. Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
    Title: Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actomyosin structure organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within calcium-dependent cell-matrix adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in memory ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in varicosity ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 7
Names
channel-kinase 1
long transient receptor potential channel 7
transient receptor potential M7
transient receptor potential-phospholipase C-interacting kinase
transient receptor potential-related protein, ChaK
NP_001157797.1
NP_067425.2
XP_036018328.1
XP_036018329.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164325.1 → NP_001157797.1  transient receptor potential cation channel subfamily M member 7 isoform 2

    See identical proteins and their annotated locations for NP_001157797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS50700.1
    UniProtKB/Swiss-Prot
    Q923J1
    UniProtKB/TrEMBL
    A2AI57
    Related
    ENSMUSP00000028843.6, ENSMUST00000028843.12
    Conserved Domains (3) summary
    smart00811
    Location:1595 → 1813
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:879 → 1100
    Ion_trans; Ion transport protein
    pfam16519
    Location:1198 → 1249
    TRPM_tetra; Tetramerization domain of TRPM

  2. NM_021450.2 → NP_067425.2  transient receptor potential cation channel subfamily M member 7 isoform 1

    See identical proteins and their annotated locations for NP_067425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732330
    Consensus CDS
    CCDS16689.1
    UniProtKB/Swiss-Prot
    Q923J1, Q9JLQ1
    Related
    ENSMUSP00000099513.4, ENSMUST00000103224.10
    Conserved Domains (3) summary
    smart00811
    Location:1596 → 1814
    Alpha_kinase; Alpha-kinase family
    pfam00520
    Location:879 → 1100
    Ion_trans; Ion transport protein
    pfam16519
    Location:1198 → 1249
    TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126633478..126718181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162435.1 → XP_036018328.1  transient receptor potential cation channel subfamily M member 7 isoform X1

    Conserved Domains (4) summary
    TIGR00870
    Location:663 → 1113
    trp; transient-receptor-potential calcium channel protein
    cd16971
    Location:1519 → 1757
    Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7
    pfam16519
    Location:1135 → 1188
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:47 → 312
    LSDAT_euk; SLOG in TRPM

  2. XM_036162436.1 → XP_036018329.1  transient receptor potential cation channel subfamily M member 7 isoform X2

    Conserved Domains (3) summary
    TIGR00870
    Location:722 → 1172
    trp; transient-receptor-potential calcium channel protein
    pfam16519
    Location:1194 → 1247
    TRPM_tetra; Tetramerisation domain of TRPM
    pfam18139
    Location:106 → 371
    LSDAT_euk; SLOG in TRPM

RNA

  1. XR_001783160.3 RNA Sequence

  2. XR_001783159.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923J1.1 GenPept UniProtKB/Swiss-Prot:Q923J1

Gene LinkOut

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