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RABIF RAB interacting factor [ Homo sapiens (human) ]

Gene ID: 5877, updated on 10-Oct-2019

Summary

Official Symbol
RABIFprovided by HGNC
Official Full Name
RAB interacting factorprovided by HGNC
Primary source
HGNC:HGNC:9797
See related
Ensembl:ENSG00000183155 MIM:603417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSS4; RASGFR3; RASGRF3
Summary
This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]
Expression
Broad expression in testis (RPKM 8.2), brain (RPKM 4.5) and 24 other tissues See more
Orthologs

Genomic context

See RABIF in Genome Data Viewer
Location:
1q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (202878282..202889149, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202847410..202858385, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tubulin alpha 3d pseudogene Neighboring gene actin gamma 1 pseudogene Neighboring gene kelch like family member 12 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 59 Neighboring gene adiponectin receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide exchange factor MSS4
Names
Ras-specific guanine-releasing factor 3
mammalian suppressor of SEC4
rab-interacting factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002871.5NP_002862.2  guanine nucleotide exchange factor MSS4

    See identical proteins and their annotated locations for NP_002862.2

    Status: REVIEWED

    Source sequence(s)
    AC098934
    Consensus CDS
    CCDS1428.1
    UniProtKB/Swiss-Prot
    P47224
    UniProtKB/TrEMBL
    Q53EV1
    Related
    ENSP00000356231.3, ENST00000367262.4
    Conserved Domains (1) summary
    cd00246
    Location:19123
    RabGEF; Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    202878282..202889149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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