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RAB3IL1 RAB3A interacting protein like 1 [ Homo sapiens (human) ]

Gene ID: 5866, updated on 5-Jul-2025
Official Symbol
RAB3IL1provided by HGNC
Official Full Name
RAB3A interacting protein like 1provided by HGNC
Primary source
HGNC:HGNC:9780
See related
Ensembl:ENSG00000167994 MIM:621025; AllianceGenome:HGNC:9780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRAB
Summary
This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]
Expression
Broad expression in testis (RPKM 14.8), ovary (RPKM 10.2) and 24 other tissues See more
Orthologs
mouse all
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See RAB3IL1 in Genome Data Viewer
Location:
11q12.2-q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61897301..61946323, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61886105..61935133, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61664773..61687756, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61615549-61616049 Neighboring gene uncharacterized LOC124902679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61624465-61624966 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61628720-61629220 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61629221-61629721 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:61642149-61642697 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61646639-61647348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61655245-61655746 Neighboring gene fatty acid desaturase 3 Neighboring gene microRNA 6746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61657348-61658037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61658038-61658726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61666908-61667879 Neighboring gene Sharpr-MPRA regulatory region 8487 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61705992-61706140 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:61709325-61709979 Neighboring gene RNA, U6 small nuclear 1243, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61711149-61711650 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61713521-61713684 Neighboring gene uncharacterized LOC107984334 Neighboring gene bestrophin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3410 Neighboring gene uncharacterized LOC399900 Neighboring gene ferritin heavy chain 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Williams JA, et al. Am J Physiol Endocrinol Metab, 2009 Mar. PMID 19088252, Free PMC Article
  2. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics. Zhang R, et al. Life Sci, 2020 Dec 1. PMID 33011223
  3. Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB. Guo Z, et al. J Biol Chem, 2013 Nov 8. PMID 24072714, Free PMC Article
  4. Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis. Quevedo MF, et al. Biochim Biophys Acta Mol Cell Res, 2019 Apr. PMID 30599141
  5. GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Luo HR, et al. Neuron, 2001 Aug 16. PMID 11516400

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
    Title: Identification of hub genes in unstable atherosclerotic plaque by conjoint analysis of bioinformatics.
  2. Rab27/Rabphilin3a/GRAB/Rab3 constitutes a signaling module in sperm exocytosis.
    Title: Grab recruitment by Rab27A-Rabphilin3a triggers Rab3A activation in human sperm exocytosis.
  3. Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.
    Title: Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
guanine nucleotide exchange factor for Rab-3A
Names
RAB3A interacting protein (rabin3)-like 1
rab3A-interacting-like protein 1
rabin3-like 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271686.2 → NP_001258615.1  guanine nucleotide exchange factor for Rab-3A isoform 2

    See identical proteins and their annotated locations for NP_001258615.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AP006260, BC022239, BC051820
    Consensus CDS
    CCDS60809.1
    UniProtKB/Swiss-Prot
    Q8TBN0
    Related
    ENSP00000301773.5, ENST00000301773.9
    Conserved Domains (1) summary
    pfam06428
    Location:162 → 196
    Sec2p; GDP/GTP exchange factor Sec2p

  2. NM_013401.4 → NP_037533.2  guanine nucleotide exchange factor for Rab-3A isoform 1

    See identical proteins and their annotated locations for NP_037533.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP006260, BC022239, BQ946081, DR004757
    Consensus CDS
    CCDS8014.1
    UniProtKB/Swiss-Prot
    Q86V32, Q8TBN0, Q9P1Q8
    Related
    ENSP00000378313.2, ENST00000394836.7
    Conserved Domains (1) summary
    pfam06428
    Location:115 → 159
    Sec2p; GDP/GTP exchange factor Sec2p

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61897301..61946323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718647.5 → XP_006718710.1  guanine nucleotide exchange factor for Rab-3A isoform X5

    UniProtKB/TrEMBL
    E9PK89
    Conserved Domains (1) summary
    pfam06428
    Location:162 → 206
    Sec2p; GDP/GTP exchange factor Sec2p

  2. XM_005274140.6 → XP_005274197.1  guanine nucleotide exchange factor for Rab-3A isoform X4

    See identical proteins and their annotated locations for XP_005274197.1

    UniProtKB/TrEMBL
    E9PK89
    Related
    ENSP00000435444.2, ENST00000531922.2
    Conserved Domains (1) summary
    pfam06428
    Location:162 → 206
    Sec2p; GDP/GTP exchange factor Sec2p

  3. XM_047427380.1 → XP_047283336.1  guanine nucleotide exchange factor for Rab-3A isoform X7

    Conserved Domains (2) summary
    cl41767
    Location:216 → 377
    Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins
    pfam06428
    Location:115 → 159
    Sec2p; GDP/GTP exchange factor Sec2p

  4. XM_011545199.3 → XP_011543501.1  guanine nucleotide exchange factor for Rab-3A isoform X6

    Conserved Domains (1) summary
    pfam06428
    Location:162 → 196
    Sec2p; GDP/GTP exchange factor Sec2p

  5. XM_011545200.3 → XP_011543502.1  guanine nucleotide exchange factor for Rab-3A isoform X8

  6. XM_011545196.3 → XP_011543498.1  guanine nucleotide exchange factor for Rab-3A isoform X1

    UniProtKB/TrEMBL
    E9PK89
    Conserved Domains (1) summary
    pfam06428
    Location:162 → 206
    Sec2p; GDP/GTP exchange factor Sec2p

  7. XM_011545197.3 → XP_011543499.1  guanine nucleotide exchange factor for Rab-3A isoform X2

    Conserved Domains (1) summary
    pfam06428
    Location:121 → 165
    Sec2p; GDP/GTP exchange factor Sec2p

  8. XM_011545198.3 → XP_011543500.1  guanine nucleotide exchange factor for Rab-3A isoform X3

    Conserved Domains (1) summary
    pfam06428
    Location:115 → 159
    Sec2p; GDP/GTP exchange factor Sec2p

  9. XM_011545201.4 → XP_011543503.1  guanine nucleotide exchange factor for Rab-3A isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61886105..61935133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369580.1 → XP_054225555.1  guanine nucleotide exchange factor for Rab-3A isoform X5

    UniProtKB/TrEMBL
    E9PK89

  2. XM_054369579.1 → XP_054225554.1  guanine nucleotide exchange factor for Rab-3A isoform X4

    UniProtKB/TrEMBL
    E9PK89

  3. XM_054369582.1 → XP_054225557.1  guanine nucleotide exchange factor for Rab-3A isoform X7

  4. XM_054369581.1 → XP_054225556.1  guanine nucleotide exchange factor for Rab-3A isoform X6

  5. XM_054369583.1 → XP_054225558.1  guanine nucleotide exchange factor for Rab-3A isoform X8

  6. XM_054369576.1 → XP_054225551.1  guanine nucleotide exchange factor for Rab-3A isoform X1

    UniProtKB/TrEMBL
    E9PK89

  7. XM_054369577.1 → XP_054225552.1  guanine nucleotide exchange factor for Rab-3A isoform X2

  8. XM_054369578.1 → XP_054225553.1  guanine nucleotide exchange factor for Rab-3A isoform X3

  9. XM_054369584.1 → XP_054225559.1  guanine nucleotide exchange factor for Rab-3A isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBN0.1 GenPept UniProtKB/Swiss-Prot:Q8TBN0

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