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RAB3B RAB3B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5865, updated on 7-Jun-2020

Summary

Official Symbol
RAB3Bprovided by HGNC
Official Full Name
RAB3B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9778
See related
Ensembl:ENSG00000169213 MIM:179510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in prostate (RPKM 6.0), brain (RPKM 3.4) and 11 other tissues See more
Orthologs

Genomic context

See RAB3B in Genome Data Viewer
Location:
1p32.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (51907956..51990700, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52373628..52456436, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nardilysin convertase Neighboring gene tRNA splicing endonuclease subunit 15 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 5937 Neighboring gene RNA, 5S ribosomal pseudogene 48 Neighboring gene ribosomal protein S26 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 8174 Neighboring gene RNA, 7SL, cytoplasmic 290, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTP-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-cysteine methylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine uptake involved in synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of synaptic vesicle cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle size IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
anchored component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-3B
Names
brain antigen RAB3B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002867.4NP_002858.2  ras-related protein Rab-3B

    See identical proteins and their annotated locations for NP_002858.2

    Status: VALIDATED

    Source sequence(s)
    AL589663, AU119030, BC005035
    Consensus CDS
    CCDS560.1
    UniProtKB/Swiss-Prot
    P20337
    Related
    ENSP00000360718.3, ENST00000371655.4
    Conserved Domains (2) summary
    smart00175
    Location:23183
    RAB; Rab subfamily of small GTPases
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    51907956..51990700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001958.1XP_016857447.1  ras-related protein Rab-3B isoform X1

    UniProtKB/Swiss-Prot
    P20337
    Conserved Domains (2) summary
    smart00175
    Location:23183
    RAB; Rab subfamily of small GTPases
    cd01865
    Location:22186
    Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
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