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RGL2 ral guanine nucleotide dissociation stimulator like 2 [ Homo sapiens (human) ]

Gene ID: 5863, updated on 17-Sep-2024

Summary

Official Symbol
RGL2provided by HGNC
Official Full Name
ral guanine nucleotide dissociation stimulator like 2provided by HGNC
Primary source
HGNC:HGNC:9769
See related
Ensembl:ENSG00000237441 MIM:602306; AllianceGenome:HGNC:9769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KE1.5; RAB2L; HKE1.5
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 40.1), prostate (RPKM 26.5) and 25 other tissues See more
Orthologs
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Genomic context

See RGL2 in Genome Data Viewer
Location:
6p21.32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33291654..33301612, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33113016..33120834, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33259431..33266719, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255009-33255542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33255543-33256076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33256611-33257144 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33265070-33265597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33265684-33266184 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33266952-33267130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33267887-33268394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33268395-33268900 Neighboring gene TAP binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33282409-33283068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33283069-33283726 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene uncharacterized LOC124901303 Neighboring gene death domain associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of ral guanine nucleotide dissociation stimulator-like 2 (RGL2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
GDS-related protein
ralGDS-like 2
ralGDS-like factor
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243738.2NP_001230667.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001230667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL050259, BX648015, DA158284
    UniProtKB/TrEMBL
    Q9BSI0
    Related
    ENST00000437840.6
    Conserved Domains (3) summary
    cd00153
    Location:566651
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:157431
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8130
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. NM_004761.5NP_004752.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

    See identical proteins and their annotated locations for NP_004752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL050259, BX648015
    Consensus CDS
    CCDS4774.1
    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9, A0A1U9X8E4, A0A1U9X8F0
    Related
    ENSP00000420211.1, ENST00000497454.6
    Conserved Domains (3) summary
    cd00153
    Location:648733
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33291654..33301612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419202.1XP_047275158.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_047419203.1XP_047275159.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  3. XM_047419201.1XP_047275157.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  4. XM_047419200.1XP_047275156.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X5

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  5. XM_047419199.1XP_047275155.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  6. XM_011514785.4XP_011513087.2  ral guanine nucleotide dissociation stimulator-like 2 isoform X6

  7. XM_047419205.1XP_047275161.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X8

  8. XM_047419204.1XP_047275160.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X7

RNA

  1. XR_007059286.1 RNA Sequence

  2. XR_007059287.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    4703139..4710957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329839.1XP_054185814.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_054329840.1XP_054185815.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  3. XM_054329837.1XP_054185812.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9, A0A1U9X8E4, A0A1U9X8F0
  4. XM_054329841.1XP_054185816.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  5. XM_054329836.1XP_054185811.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  6. XM_054329838.1XP_054185813.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  7. XM_054329842.1XP_054185817.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X9

  8. XM_054329843.1XP_054185818.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X10

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    4535172..4542990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330324.1XP_054186299.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_054330325.1XP_054186300.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  3. XM_054330322.1XP_054186297.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9, A0A1U9X8E4, A0A1U9X8F0
  4. XM_054330326.1XP_054186301.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  5. XM_054330321.1XP_054186296.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  6. XM_054330323.1XP_054186298.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  7. XM_054330327.1XP_054186302.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X12

  8. XM_054330328.1XP_054186303.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X13

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    4727590..4735521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330841.1XP_054186816.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_054330840.1XP_054186815.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  3. XM_054330842.1XP_054186817.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  4. XM_054330838.1XP_054186813.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  5. XM_054330839.1XP_054186814.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  6. XM_054330843.1XP_054186818.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X14

  7. XM_054330844.1XP_054186819.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X15

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    4486078..4494006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331101.1XP_054187076.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_054331100.1XP_054187075.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  3. XM_054331098.1XP_054187073.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X11

    UniProtKB/Swiss-Prot
    B4DG72, O15211, Q5STK0, Q9Y3F3
    UniProtKB/TrEMBL
    A0A024RCS9, A0A1U9X8E4, A0A1U9X8F0
  4. XM_054331102.1XP_054187077.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  5. XM_054331097.1XP_054187072.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  6. XM_054331099.1XP_054187074.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  7. XM_054331103.1XP_054187078.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X16

  8. XM_054331104.1XP_054187079.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X17

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33113016..33120834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356133.1XP_054212108.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  2. XM_054356134.1XP_054212109.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X4

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  3. XM_054356135.1XP_054212110.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  4. XM_054356131.1XP_054212106.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A1U9X8E4, A0A1U9X8F0
  5. XM_054356132.1XP_054212107.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    UniProtKB/TrEMBL
    Q9BSI0
  6. XM_054356136.1XP_054212111.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X18

  7. XM_054356137.1XP_054212112.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X19