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RGL2 ral guanine nucleotide dissociation stimulator like 2 [ Homo sapiens (human) ]

Gene ID: 5863, updated on 7-Dec-2018

Summary

Official Symbol
RGL2provided by HGNC
Official Full Name
ral guanine nucleotide dissociation stimulator like 2provided by HGNC
Primary source
HGNC:HGNC:9769
See related
Ensembl:ENSG00000237441 MIM:602306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KE1.5; RAB2L; HKE1.5
Expression
Ubiquitous expression in spleen (RPKM 40.1), prostate (RPKM 26.5) and 25 other tissues See more
Orthologs

Genomic context

See RGL2 in Genome Data Viewer
Location:
6p21.32
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (33291654..33299388, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33259431..33267386, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 46 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene TAP binding protein Neighboring gene zinc finger and BTB domain containing 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of ral guanine nucleotide dissociation stimulator-like 2 (RGL2) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ras guanyl-nucleotide exchange factor activity NAS
Non-traceable Author Statement
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of Ral protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
GDS-related protein
ralGDS-like 2
ralGDS-like factor
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243738.1NP_001230667.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001230667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL050259, BX648015, DA158284
    UniProtKB/Swiss-Prot
    O15211
    Conserved Domains (3) summary
    cd00153
    Location:566651
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:157431
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8130
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. NM_004761.5NP_004752.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

    See identical proteins and their annotated locations for NP_004752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL050259, BX648015
    Consensus CDS
    CCDS4774.1
    UniProtKB/Swiss-Prot
    O15211
    UniProtKB/TrEMBL
    A0A024RCS9
    Related
    ENSP00000420211.1, ENST00000497454.5
    Conserved Domains (3) summary
    cd00153
    Location:648733
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    33291654..33299388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446505.1XP_024302273.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    Conserved Domains (3) summary
    cd00153
    Location:687772
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239552
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  2. XM_011514781.1XP_011513083.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

    See identical proteins and their annotated locations for XP_011513083.1

    Conserved Domains (3) summary
    cd00153
    Location:541626
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:157406
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8130
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
  3. XM_011514785.3XP_011513087.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

    See identical proteins and their annotated locations for XP_011513087.1

    Conserved Domains (2) summary
    smart00147
    Location:157431
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:8130
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RNA

  1. XR_926294.2 RNA Sequence

    Related
    ENST00000437840.6

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    4703139..4710873 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    4535172..4542906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    4727590..4735324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    4486078..4493809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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