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RAB1A RAB1A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5861, updated on 5-Apr-2020

Summary

Official Symbol
RAB1Aprovided by HGNC
Official Full Name
RAB1A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9758
See related
Ensembl:ENSG00000138069 MIM:179508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB1; YPT1
Summary
This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in kidney (RPKM 68.0), thyroid (RPKM 58.5) and 25 other tissues See more
Orthologs

Genomic context

See RAB1A in Genome Data Viewer
Location:
2p14
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (65086854..65130301, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65313988..65357435, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984063 Neighboring gene RNA, U6 small nuclear 548, pseudogene Neighboring gene solute carrier family 1 member 4 Neighboring gene long intergenic non-protein coding RNA 2576 Neighboring gene centrosomal protein 68 Neighboring gene VDAC2 pseudogene 5 Neighboring gene actin related protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env Overexpression of TBC1D20, RAB1A, or RAB1B results in abnormal HIV-1 gp41 migration, suggesting that a precise regulation of the RAB1/TBC1D20 axis is necessary for proper HIV-1 gp41 processing PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564B163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
PubMed 
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
cargo loading into COPII-coated vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-8 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanosome transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
virion assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
virion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus HDA PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
transport vesicle membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-1A
Names
GTP binding protein Rab1a
RAB1, member RAS oncogene family
Rab GTPase YPT1 homolog
YPT1-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004161.5NP_004152.1  ras-related protein Rab-1A isoform 1

    See identical proteins and their annotated locations for NP_004152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AI768809, AK055927, BC000905, DC352417
    Consensus CDS
    CCDS46306.1
    UniProtKB/Swiss-Prot
    P62820
    UniProtKB/TrEMBL
    Q5U0I6
    Related
    ENSP00000387286.3, ENST00000409784.8
    Conserved Domains (1) summary
    cd01869
    Location:10175
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1
  2. NM_015543.1NP_056358.1  ras-related protein Rab-1A isoform 2

    See identical proteins and their annotated locations for NP_056358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate segments in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI768809, AK055927, AL050268, DC352417
    Consensus CDS
    CCDS46305.1
    UniProtKB/Swiss-Prot
    P62820
    Related
    ENSP00000381540.3, ENST00000398529.7
    Conserved Domains (1) summary
    cl21455
    Location:1099
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    65086854..65130301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264468.2XP_005264525.1  ras-related protein Rab-1A isoform X1

    See identical proteins and their annotated locations for XP_005264525.1

    UniProtKB/TrEMBL
    B7Z8M7
    Related
    ENSP00000386451.1, ENST00000409892.5
    Conserved Domains (1) summary
    cl21455
    Location:10143
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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