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PZP PZP alpha-2-macroglobulin like [ Homo sapiens (human) ]

Gene ID: 5858, updated on 24-Nov-2020

Summary

Official Symbol
PZPprovided by HGNC
Official Full Name
PZP alpha-2-macroglobulin likeprovided by HGNC
Primary source
HGNC:HGNC:9750
See related
Ensembl:ENSG00000126838 MIM:176420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPAMD6
Summary
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
Expression
Biased expression in liver (RPKM 5.3), endometrium (RPKM 1.0) and 2 other tissues See more
Orthologs

Genomic context

See PZP in Genome Data Viewer
Location:
12p13.31
Exon count:
38
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (9140730..9208395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9301436..9360966, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor G1 Neighboring gene keratin 17 pseudogene 8 Neighboring gene BTG anti-proliferation factor 1 pseudogene 1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 12 Neighboring gene microRNA 1244-3 Neighboring gene alpha-2-macroglobulin pseudogene 1 Neighboring gene prothymosin alpha pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
female pregnancy TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pregnancy zone protein
Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Pregnancy zone protein
pregnancy-zone protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052998.1 RefSeqGene

    Range
    4976..64531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002864.3NP_002855.2  pregnancy zone protein precursor

    See identical proteins and their annotated locations for NP_002855.2

    Status: REVIEWED

    Source sequence(s)
    AC010175, DB040351, X54380
    Consensus CDS
    CCDS8600.1
    Related
    ENSP00000261336.2, ENST00000261336.7
    Conserved Domains (7) summary
    cd02897
    Location:9641270
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:744834
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam05326
    Location:796891
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:13821469
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10161272
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    9140730..9208395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019763.1XP_016875252.1  pregnancy zone protein isoform X1

    Conserved Domains (7) summary
    cd02897
    Location:9641270
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:744834
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam05326
    Location:796891
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:13821464
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10161272
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  2. XM_011520805.2XP_011519107.1  pregnancy zone protein isoform X2

    Conserved Domains (7) summary
    cd02897
    Location:9631269
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:743833
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam05326
    Location:795890
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:13811463
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10151271
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  3. XM_017019765.1XP_016875254.1  pregnancy zone protein isoform X4

  4. XM_011520804.2XP_011519106.1  pregnancy zone protein isoform X1

    Conserved Domains (7) summary
    cd02897
    Location:9641270
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:744834
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam05326
    Location:796891
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07677
    Location:13821464
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10161272
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  5. XM_024449111.1XP_024304879.1  pregnancy zone protein isoform X5

    Conserved Domains (5) summary
    cd02897
    Location:7501056
    A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
    pfam00207
    Location:613700
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:1289
    A2M_N; MG2 domain
    pfam07677
    Location:11681255
    A2M_recep; A-macroglobulin receptor
    pfam07703
    Location:324472
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
  6. XM_017019764.1XP_016875253.1  pregnancy zone protein isoform X3

  7. XM_011520806.1XP_011519108.1  pregnancy zone protein isoform X6

    Conserved Domains (5) summary
    pfam00207
    Location:744834
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam05326
    Location:796891
    SVA; Seminal vesicle autoantigen (SVA)
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl08267
    Location:9641045
    ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
  8. XM_017019767.1XP_016875256.1  pregnancy zone protein isoform X7

  9. XM_011520807.2XP_011519109.1  pregnancy zone protein isoform X8

    Conserved Domains (3) summary
    pfam00207
    Location:744830
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:128220
    A2M_N; MG2 domain
    pfam07703
    Location:457602
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region

RNA

  1. XR_001748834.1 RNA Sequence

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