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LY6G6D lymphocyte antigen 6 family member G6D [ Homo sapiens (human) ]

Gene ID: 58530, updated on 21-Dec-2019

Summary

Official Symbol
LY6G6Dprovided by HGNC
Official Full Name
lymphocyte antigen 6 family member G6Dprovided by HGNC
Primary source
HGNC:HGNC:13935
See related
Ensembl:ENSG00000244355 MIM:606038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G6D; NG25; LY6-D; MEGT1; C6orf23
Summary
LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]
Expression
Biased expression in prostate (RPKM 1.8), testis (RPKM 1.5) and 6 other tissues See more
Orthologs

Genomic context

See LY6G6D in Genome Data Viewer
Location:
6p21.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (31715356..31717804)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31683048..31685698)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LY6G6F-LY6G6D readthrough Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene lymphocyte antigen 6 family member G6E Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene dimethylarginine dimethylaminohydrolase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Readthrough LY6G6F-LY6G6D

Readthrough gene: LY6G6F-LY6G6D, Included gene: LY6G6F

Homology

Clone Names

  • MGC150334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lymphocyte antigen 6 complex locus protein G6d
Names
lymphocyte antigen 6 complex, locus G6D
lymphocyte antigen-6 G6D
megakaryocyte-enhanced gene transcript 1 protein
protein Ly6-D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021246.2NP_067069.2  lymphocyte antigen 6 complex locus protein G6d precursor

    See identical proteins and their annotated locations for NP_067069.2

    Status: VALIDATED

    Source sequence(s)
    AJ315535
    Consensus CDS
    CCDS34404.1
    UniProtKB/Swiss-Prot
    O95868
    UniProtKB/TrEMBL
    A0A1L6Z9X4
    Related
    ENSP00000364985.3, ENST00000375825.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    31715356..31717804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    3192640..3195092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    2963118..2965566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    3020406..3022850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    3057233..3059679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    2971176..2973618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p13 ALT_REF_LOCI_7

    Range
    3014652..3017100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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