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MID1IP1 MID1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 58526, updated on 17-Jan-2022

Summary

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Official Symbol
MID1IP1provided by HGNC
Official Full Name
MID1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:20715
See related
Ensembl:ENSG00000165175 MIM:300961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S14R; MIG12; THRSPL; G12-like; STRAIT11499
Summary
Predicted to enable identical protein binding activity and protein C-terminus binding activity. Predicted to be involved in several processes, including negative regulation of microtubule depolymerization; positive regulation of fatty acid biosynthetic process; and protein polymerization. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bone marrow (RPKM 21.2), fat (RPKM 16.5) and 25 other tissues See more
Orthologs
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Genomic context

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See MID1IP1 in Genome Data Viewer
Location:
Xp11.4
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (38801459..38806532)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (38660712..38665785)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373174 Neighboring gene Sharpr-MPRA regulatory region 799 Neighboring gene MID1IP1 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 591, pseudogene Neighboring gene uncharacterized LOC105373175

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2. Jung JH, et al. Cells, 2020 Apr 16. PMID 32316188, Free PMC Article
  2. Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis. Wang Q, et al. Mol Med Rep, 2016 Jun. PMID 27082501, Free PMC Article
  3. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53. Jung JH, et al. Biomolecules, 2021 Oct 10. PMID 34680125, Free PMC Article
  4. MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase. Izumi A, et al. Biochem Biophys Res Commun, 2021 Aug 27. PMID 34153683
  5. Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. Berti C, et al. BMC Cell Biol, 2004 Feb 29. PMID 15070402, Free PMC Article

See all (28) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
    Title: Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
  2. MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
    Title: MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
  3. Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2.
    Title: Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2.
  4. The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS.
    Title: Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis.
  5. show that MIG12, a 22 kDa cytosolic protein of previously unknown function, binds to acetyl-CoA carboxylase and lowers the threshold for citrate activation into the physiological range.
    Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mid1-interacting protein 1
Names
MID1 interacting G12-like protein
MID1 interacting protein 1 (gastrulation specific G12-like)
gastrulation specific G12 homolog
spot 14-R
spot 14-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098790.2 → NP_001092260.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_001092260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AW086438, BC019332
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    Q9NPA3
    Related
    ENSP00000367735.3, ENST00000378474.3
    Conserved Domains (1) summary
    pfam07084
    Location:3 → 177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

  2. NM_001098791.2 → NP_001092261.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_001092261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AW086438, BC019332, DA138791
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    Q9NPA3
    Related
    ENSP00000416670.1, ENST00000457894.5
    Conserved Domains (1) summary
    pfam07084
    Location:3 → 177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

  3. NM_021242.6 → NP_067065.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_067065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF241728, AJ272057, AW086438, BC008908, CN417714, DA138791, DA449860, DA995619
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    Q9NPA3
    Related
    ENSP00000483547.1, ENST00000614558.3
    Conserved Domains (1) summary
    pfam07084
    Location:3 → 177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    38801459..38806532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPA3.1 GenPept UniProtKB/Swiss-Prot:Q9NPA3

Gene LinkOut

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