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MID1IP1 MID1 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 58526, updated on 6-Sep-2022

Summary

Official Symbol
MID1IP1provided by HGNC
Official Full Name
MID1 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:20715
See related
Ensembl:ENSG00000165175 MIM:300961; AllianceGenome:HGNC:20715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S14R; MIG12; THRSPL; G12-like; STRAIT11499
Summary
Predicted to enable identical protein binding activity and protein C-terminus binding activity. Predicted to be involved in several processes, including negative regulation of microtubule depolymerization; positive regulation of fatty acid biosynthetic process; and protein polymerization. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 21.2), fat (RPKM 16.5) and 25 other tissues See more
Orthologs
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Genomic context

See MID1IP1 in Genome Data Viewer
Location:
Xp11.4
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (38801459..38806532)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (38200942..38206015)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (38660712..38665785)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene tetraspanin 7 Neighboring gene RNA, U7 small nuclear 7 pseudogene Neighboring gene Sharpr-MPRA regulatory region 799 Neighboring gene MID1IP1 antisense RNA 1 Neighboring gene uncharacterized LOC124905178 Neighboring gene uncharacterized LOC124905177

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mid1-interacting protein 1
Names
MID1 interacting G12-like protein
MID1 interacting protein 1 (gastrulation specific G12-like)
gastrulation specific G12 homolog
spot 14-R
spot 14-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098790.2NP_001092260.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_001092260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AW086438, BC019332
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    D3DWB2, Q9NPA3
    Related
    ENSP00000367735.3, ENST00000378474.3
    Conserved Domains (1) summary
    pfam07084
    Location:3177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14
  2. NM_001098791.2NP_001092261.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_001092261.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AW086438, BC019332, DA138791
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    D3DWB2, Q9NPA3
    Related
    ENSP00000416670.1, ENST00000457894.5
    Conserved Domains (1) summary
    pfam07084
    Location:3177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14
  3. NM_021242.6NP_067065.1  mid1-interacting protein 1

    See identical proteins and their annotated locations for NP_067065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF241728, AJ272057, AW086438, BC008908, CN417714, DA138791, DA449860, DA995619
    Consensus CDS
    CCDS14249.1
    UniProtKB/Swiss-Prot
    D3DWB2, Q9NPA3
    Related
    ENSP00000483547.1, ENST00000614558.3
    Conserved Domains (1) summary
    pfam07084
    Location:3177
    Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    38801459..38806532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    38200942..38206015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)