MID1IP1 MID1 interacting protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MID1IP1provided by HGNC
Official Full Name: MID1 interacting protein 1provided by HGNC
Primary source: HGNC:HGNC:20715
See related: Ensembl:ENSG00000165175 MIM:300961; AllianceGenome:HGNC:20715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S14R; MIG12; THRSPL; G12-like; STRAIT11499
Summary: Predicted to enable enzyme activator activity; identical protein binding activity; and ligase regulator activity. Predicted to be involved in several processes, including negative regulation of microtubule depolymerization; positive regulation of fatty acid biosynthetic process; and positive regulation of ligase activity. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in bone marrow (RPKM 21.2), fat (RPKM 16.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xp11.4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (38801459..38806532)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (38200942..38206015)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (38660712..38665785)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Midline 1 interacting protein 1 promotes cancer metastasis through FOS-like 1-mediated matrix metalloproteinase 9 signaling in HCC.
Title: Midline 1 interacting protein 1 promotes cancer metastasis through FOS-like 1-mediated matrix metalloproteinase 9 signaling in HCC.
Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
Title: Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
Title: MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2.
Title: Colocalization of MID1IP1 and c-Myc is Critically Involved in Liver Cancer Growth via Regulation of Ribosomal Protein L5 and L11 and CNOT2.
The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS.
Title: Spot14/Spot14R expression may be involved in MSC adipogenic differentiation in patients with adolescent idiopathic scoliosis.
show that MIG12, a 22 kDa cytosolic protein of previously unknown function, binds to acetyl-CoA carboxylase and lowers the threshold for citrate activation into the physiological range.
Title: Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed
Knockdown of MID1 interacting protein 1 (MID1IP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables ligase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ligase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polymerization	IEA Inferred from Electronic Annotation more info
involved_in protein polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mid1-interacting protein 1

Names: MID1 interacting G12-like protein; MID1 interacting protein 1 (gastrulation specific G12-like); gastrulation specific G12 homolog; spot 14-R; spot 14-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098790.2 → NP_001092260.1 mid1-interacting protein 1

See identical proteins and their annotated locations for NP_001092260.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AW086438, BC019332

Consensus CDS

CCDS14249.1

UniProtKB/Swiss-Prot

D3DWB2, Q9NPA3

Related

ENSP00000367735.3, ENST00000378474.3

Conserved Domains (1) summary

pfam07084
Location:3 → 177

Spot_14; Thyroid hormone-inducible hepatic protein Spot 14
NM_001098791.2 → NP_001092261.1 mid1-interacting protein 1

See identical proteins and their annotated locations for NP_001092261.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AW086438, BC019332, DA138791

Consensus CDS

CCDS14249.1

UniProtKB/Swiss-Prot

D3DWB2, Q9NPA3

Related

ENSP00000416670.1, ENST00000457894.5

Conserved Domains (1) summary

pfam07084
Location:3 → 177

Spot_14; Thyroid hormone-inducible hepatic protein Spot 14
NM_021242.6 → NP_067065.1 mid1-interacting protein 1

See identical proteins and their annotated locations for NP_067065.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.

Source sequence(s)

AF241728, AJ272057, AW086438, BC008908, CN417714, DA138791, DA449860, DA995619

Consensus CDS

CCDS14249.1

UniProtKB/Swiss-Prot

D3DWB2, Q9NPA3

Related

ENSP00000483547.1, ENST00000614558.3

Conserved Domains (1) summary

pfam07084
Location:3 → 177

Spot_14; Thyroid hormone-inducible hepatic protein Spot 14