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WIZ WIZ zinc finger [ Homo sapiens (human) ]

Gene ID: 58525, updated on 5-May-2020

Summary

Official Symbol
WIZprovided by HGNC
Official Full Name
WIZ zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:30917
See related
Ensembl:ENSG00000011451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF803
Expression
Ubiquitous expression in testis (RPKM 8.9), fat (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See WIZ in Genome Data Viewer
Location:
19p13.12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15419978..15449956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15532318..15560767, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 8 Neighboring gene Sharpr-MPRA regulatory region 9920 Neighboring gene A-kinase anchoring protein 8 like Neighboring gene microRNA 1470 Neighboring gene RAS protein activator like 3 Neighboring gene peptidoglycan recognition protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SET domain binding IEA
Inferred from Electronic Annotation
more info
 
histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein Wiz
Names
widely interspaced zinc finger motifs
widely-interspaced zinc finger-containing protein
zinc finger protein 803

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330395.4NP_001317324.2  protein Wiz isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006128, AC007059
    Consensus CDS
    CCDS82308.1
    Related
    ENSP00000501256.1, ENST00000674089.1
  2. NM_001371589.1NP_001358518.1  protein Wiz isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006128, AC007059, AC011492
    Related
    ENSP00000500993.1, ENST00000673675.1
  3. NM_001371603.5NP_001358532.2  protein Wiz isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC006128, AC007059
    Related
    ENSP00000501300.1, ENST00000674001.1
  4. NM_021241.3NP_067064.2  protein Wiz isoform 1

    See identical proteins and their annotated locations for NP_067064.2

    Status: VALIDATED

    Source sequence(s)
    AC006128, AC011492, AK131404, AL390184, BC007551, BC014220
    Consensus CDS
    CCDS42516.1
    UniProtKB/Swiss-Prot
    O95785
    Related
    ENSP00000263381.5, ENST00000263381.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15419978..15449956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260007.4XP_005260064.1  protein Wiz isoform X4

    Related
    ENSP00000495441.1, ENST00000643092.1
    Conserved Domains (1) summary
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_005260005.4XP_005260062.1  protein Wiz isoform X2

    Conserved Domains (1) summary
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_005260006.4XP_005260063.1  protein Wiz isoform X3

    Conserved Domains (1) summary
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_005260008.3XP_005260065.1  protein Wiz isoform X5

    See identical proteins and their annotated locations for XP_005260065.1

  5. XM_005260011.3XP_005260068.1  protein Wiz isoform X8

    Conserved Domains (1) summary
    COG5411
    Location:259328
    COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]
  6. XM_006722828.3XP_006722891.1  protein Wiz isoform X6

  7. XM_005260010.3XP_005260067.1  protein Wiz isoform X7

    See identical proteins and their annotated locations for XP_005260067.1

    UniProtKB/TrEMBL
    M0QXA7
    Related
    ENSP00000373933.5, ENST00000389282.8
    Conserved Domains (1) summary
    COG5411
    Location:132201
    COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]
  8. XM_011528163.2XP_011526465.1  protein Wiz isoform X7

    See identical proteins and their annotated locations for XP_011526465.1

    UniProtKB/TrEMBL
    M0QXA7
    Related
    ENSP00000469022.1, ENST00000599910.6
    Conserved Domains (1) summary
    COG5411
    Location:132201
    COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]
  9. XM_024451629.1XP_024307397.1  protein Wiz isoform X7

    Related
    ENSP00000445824.1, ENST00000545156.5
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