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DMRT3 doublesex and mab-3 related transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 58524, updated on 1-Jun-2020

Summary

Official Symbol
DMRT3provided by HGNC
Official Full Name
doublesex and mab-3 related transcription factor 3provided by HGNC
Primary source
HGNC:HGNC:13909
See related
Ensembl:ENSG00000064218 MIM:614754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMRTA3
Expression
Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues See more
Orthologs

Genomic context

See DMRT3 in Genome Data Viewer
Location:
9p24.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (976655..991732)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (976968..991732)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene VISTA enhancer hs112 Neighboring gene RNA, U6 small nuclear 1073, pseudogene Neighboring gene doublesex and mab-3 related transcription factor 2 Neighboring gene H3 histone pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
male sex differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sex differentiation NAS
Non-traceable Author Statement
more info
PubMed 
transmission of nerve impulse IEA
Inferred from Electronic Annotation
more info
 
ventral spinal cord interneuron specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
doublesex- and mab-3-related transcription factor 3
Names
DMRT-like family A3
testis-specific protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021240.4NP_067063.1  doublesex- and mab-3-related transcription factor 3

    See identical proteins and their annotated locations for NP_067063.1

    Status: VALIDATED

    Source sequence(s)
    AF193873, AI052121, AL136365, BC113584
    Consensus CDS
    CCDS6443.1
    UniProtKB/Swiss-Prot
    Q9NQL9
    Related
    ENSP00000190165.2, ENST00000190165.3
    Conserved Domains (2) summary
    cd14419
    Location:247289
    CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)
    pfam00751
    Location:2571
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    976655..991732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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