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RBM25 RNA binding motif protein 25 [ Homo sapiens (human) ]

Gene ID: 58517, updated on 8-Jul-2019

Summary

Official Symbol
RBM25provided by HGNC
Official Full Name
RNA binding motif protein 25provided by HGNC
Primary source
HGNC:HGNC:23244
See related
Ensembl:ENSG00000119707 MIM:612427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S164; NET52; RNPC7; Snu71; RED120; fSAP94
Expression
Ubiquitous expression in bone marrow (RPKM 31.7), lymph node (RPKM 25.2) and 25 other tissues See more
Orthologs

Genomic context

See RBM25 in Genome Data Viewer
Location:
14q24.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73058532..73123899)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73525221..73588749)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene uncharacterized LOC105370560 Neighboring gene RNA, 7SL, cytoplasmic 586, pseudogene Neighboring gene required for meiotic nuclear division 1 homolog (S. cerevisiae) pseudogene Neighboring gene presenilin 1 Neighboring gene uncharacterized LOC101928123 Neighboring gene papilin, proteoglycan like sulfated glycoprotein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of RNA binding motif protein 25 (RBM25) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Spliceosome, organism-specific biosystem (from KEGG)
    Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
  • Spliceosome, conserved biosystem (from KEGG)
    Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105088, MGC117168

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 25
Names
Arg/Glu/Asp-rich protein, 120 kDa
RNA-binding region (RNP1, RRM) containing 7
RNA-binding region-containing protein 7
U1 small nuclear ribonucleoprotein 1SNRP homolog
arg/Glu/Asp-rich protein of 120 kDa
functional spliceosome-associated protein 94

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021239.3NP_067062.1  RNA-binding protein 25

    See identical proteins and their annotated locations for NP_067062.1

    Status: VALIDATED

    Source sequence(s)
    AC004858, AL442663
    Consensus CDS
    CCDS32113.1
    UniProtKB/Swiss-Prot
    P49756
    Related
    ENSP00000261973.7, ENST00000261973.12
    Conserved Domains (2) summary
    smart00311
    Location:763836
    PWI; PWI, domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73058532..73123899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537044.3XP_011535346.1  RNA-binding protein 25 isoform X1

    See identical proteins and their annotated locations for XP_011535346.1

    UniProtKB/Swiss-Prot
    P49756
    Related
    ENSP00000431150.1, ENST00000527432.5
    Conserved Domains (2) summary
    smart00311
    Location:763836
    PWI; PWI, domain in splicing factors
    cd12446
    Location:87169
    RRM_RBM25; RNA recognition motif in eukaryotic RNA-binding protein 25 and similar proteins
  2. XM_024449680.1XP_024305448.1  RNA-binding protein 25 isoform X2

    Conserved Domains (1) summary
    smart00311
    Location:558631
    PWI; PWI, domain in splicing factors

RNA

  1. XR_943501.3 RNA Sequence

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