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DLGAP3 DLG associated protein 3 [ Homo sapiens (human) ]

Gene ID: 58512, updated on 12-Aug-2018

Summary

Official Symbol
DLGAP3provided by HGNC
Official Full Name
DLG associated protein 3provided by HGNC
Primary source
HGNC:HGNC:30368
See related
Ensembl:ENSG00000116544 MIM:611413; Vega:OTTHUMG00000004049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP3; SAPAP3
Expression
Biased expression in brain (RPKM 6.5) and testis (RPKM 1.3) See more
Orthologs

Genomic context

See DLGAP3 in Genome Data Viewer
Location:
1p34.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (34862120..34929585, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35331037..35391083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378642 Neighboring gene gap junction protein alpha 4 Neighboring gene small integral membrane protein 12 Neighboring gene uncharacterized LOC653160 Neighboring gene transmembrane protein 35B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
modification of synaptic structure IEA
Inferred from Electronic Annotation
more info
 
signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cholinergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
disks large-associated protein 3
Names
DAP-3
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
discs large homolog associated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080418.2NP_001073887.1  disks large-associated protein 3

    See identical proteins and their annotated locations for NP_001073887.1

    Status: VALIDATED

    Source sequence(s)
    AC114490, AL122010
    Consensus CDS
    CCDS30670.1
    UniProtKB/Swiss-Prot
    O95886
    Related
    ENSP00000362444.1, OTTHUMP00000004180, ENST00000373347.5, OTTHUMT00000011554
    Conserved Domains (1) summary
    pfam03359
    Location:628979
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    34862120..34929585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541879.2XP_011540181.1  disks large-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011540181.1

    UniProtKB/Swiss-Prot
    O95886
    Conserved Domains (1) summary
    pfam03359
    Location:628979
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. XM_011541880.2XP_011540182.1  disks large-associated protein 3 isoform X2

    Conserved Domains (1) summary
    pfam03359
    Location:131482
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
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