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ARHGAP22 Rho GTPase activating protein 22 [ Homo sapiens (human) ]

Gene ID: 58504, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP22provided by HGNC
Official Full Name
Rho GTPase activating protein 22provided by HGNC
Primary source
HGNC:HGNC:30320
See related
Ensembl:ENSG00000128805 MIM:610585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RhoGAP2; RhoGap22
Summary
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ARHGAP22 in Genome Data Viewer
Location:
10q11.22-q11.23
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (48429831..48656265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49654068..49864310, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene WDFY family member 4 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene uncharacterized LOC105378299

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of conduct disorder symptomatology.
GeneReviews: Not available
Genome-wide association study of diabetic retinopathy in a Taiwanese population.
GeneReviews: Not available
The molecular genetic architecture of self-employment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 22
Names
rho-type GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053158.1 RefSeqGene

    Range
    5001..215230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256024.2NP_001242953.1  rho GTPase-activating protein 22 isoform 1

    See identical proteins and their annotated locations for NP_001242953.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC016397, AC016399, BC126444, DB338179
    Consensus CDS
    CCDS58080.1
    UniProtKB/Swiss-Prot
    Q7Z5H3
    Related
    ENSP00000412461.2, ENST00000417912.6
    Conserved Domains (3) summary
    cd04390
    Location:167365
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:36151
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:606694
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001256025.3NP_001242954.1  rho GTPase-activating protein 22 isoform 2

    See identical proteins and their annotated locations for NP_001242954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AK293579, AY324801, DC391765
    Consensus CDS
    CCDS58081.1
    UniProtKB/Swiss-Prot
    Q7Z5H3
    Related
    ENSP00000416701.2, ENST00000435790.6
    Conserved Domains (4) summary
    cd04390
    Location:157355
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44150
    PH; PH domain
    cl05005
    Location:556685
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. NM_001256026.2NP_001242955.1  rho GTPase-activating protein 22 isoform 4

    See identical proteins and their annotated locations for NP_001242955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, uses an alternate in-frame splice site in a 5' exon, and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016397, AK127586, DB338179
    Consensus CDS
    CCDS58079.1
    UniProtKB/Swiss-Prot
    Q7Z5H3
    Related
    ENSP00000410054.2, ENST00000417247.6
    Conserved Domains (4) summary
    cd04390
    Location:61259
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:2954
    PH; PH domain
    cl05005
    Location:460589
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  4. NM_001347735.2NP_001334664.1  rho GTPase-activating protein 22 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
  5. NM_001347736.2NP_001334665.1  rho GTPase-activating protein 22 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC016399, AC068898
    Conserved Domains (1) summary
    cl17171
    Location:4284
    PH-like; Pleckstrin homology-like domain
  6. NM_001347737.2NP_001334666.1  rho GTPase-activating protein 22 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC016399
  7. NM_001347738.2NP_001334667.1  rho GTPase-activating protein 22 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC016397, AC016399, AC068898
    Consensus CDS
    CCDS58081.1
    UniProtKB/Swiss-Prot
    Q7Z5H3
  8. NM_021226.4NP_067049.2  rho GTPase-activating protein 22 isoform 3

    See identical proteins and their annotated locations for NP_067049.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter compared with isoform 1.
    Source sequence(s)
    AY324801
    Consensus CDS
    CCDS7227.1
    UniProtKB/Swiss-Prot
    Q7Z5H3
    Related
    ENSP00000249601.4, ENST00000249601.8
    Conserved Domains (4) summary
    cd04390
    Location:151349
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:36151
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:38144
    PH; PH domain
    cl05005
    Location:550679
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RNA

  1. NR_045675.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains alternate 5' exons and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016397, AK055937, DB338179
    Related
    ENST00000460425.1
  2. NR_144642.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
  3. NR_144643.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
  4. NR_144644.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
  5. NR_144645.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399
  6. NR_144646.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC016397, AC016399

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    48429831..48656265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540013.3XP_011538315.1  rho GTPase-activating protein 22 isoform X7

    Conserved Domains (3) summary
    cd04390
    Location:173363
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44150
    PH; PH domain
  2. XM_024448100.1XP_024303868.1  rho GTPase-activating protein 22 isoform X8

    Conserved Domains (2) summary
    cd04390
    Location:157347
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
  3. XM_017016476.1XP_016871965.1  rho GTPase-activating protein 22 isoform X9

  4. XM_011540015.3XP_011538317.1  rho GTPase-activating protein 22 isoform X11

    Conserved Domains (3) summary
    cd04390
    Location:173351
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:44150
    PH; PH domain
  5. XM_011540003.1XP_011538305.1  rho GTPase-activating protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011538305.1

    Conserved Domains (3) summary
    cd04390
    Location:173371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612700
    SMC_N; RecF/RecN/SMC N terminal domain
  6. XM_011540006.2XP_011538308.1  rho GTPase-activating protein 22 isoform X3

    Conserved Domains (4) summary
    cd04390
    Location:114312
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:44111
    PH; PH domain
    cl05005
    Location:513642
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:42127
    PH-like; Pleckstrin homology-like domain
  7. XM_011540002.2XP_011538304.1  rho GTPase-activating protein 22 isoform X1

    See identical proteins and their annotated locations for XP_011538304.1

    Conserved Domains (3) summary
    cd04390
    Location:173371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612700
    SMC_N; RecF/RecN/SMC N terminal domain
  8. XM_024448099.1XP_024303867.1  rho GTPase-activating protein 22 isoform X1

    Conserved Domains (3) summary
    cd04390
    Location:173371
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cd13378
    Location:42157
    PH_RhoGAP2; Rho GTPase activating protein 2 Pleckstrin homology (PH) domain
    cl25732
    Location:612700
    SMC_N; RecF/RecN/SMC N terminal domain
  9. XM_024448101.1XP_024303869.1  rho GTPase-activating protein 22 isoform X10

    Conserved Domains (2) summary
    cl02570
    Location:147
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl25732
    Location:288376
    SMC_N; RecF/RecN/SMC N terminal domain
  10. XM_011540011.2XP_011538313.1  rho GTPase-activating protein 22 isoform X5

    Conserved Domains (2) summary
    cd04390
    Location:18216
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl05005
    Location:417546
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  11. XM_005270014.3XP_005270071.1  rho GTPase-activating protein 22 isoform X4

    Related
    ENSP00000363287.1, ENST00000374172.5
    Conserved Domains (4) summary
    cd04390
    Location:77275
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:2954
    PH; PH domain
    cl05005
    Location:476605
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  12. XM_011540005.1XP_011538307.1  rho GTPase-activating protein 22 isoform X2

    Conserved Domains (4) summary
    cd04390
    Location:77275
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:2954
    PH; PH domain
    cl05005
    Location:476605
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    cl17171
    Location:1861
    PH-like; Pleckstrin homology-like domain
  13. XM_017016471.2XP_016871960.1  rho GTPase-activating protein 22 isoform X6

    Conserved Domains (2) summary
    cd04390
    Location:5203
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl05005
    Location:404533
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  14. XM_011540012.3XP_011538314.1  rho GTPase-activating protein 22 isoform X6

    Conserved Domains (2) summary
    cd04390
    Location:5203
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    cl05005
    Location:404533
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  15. XM_024448103.1XP_024303871.1  rho GTPase-activating protein 22 isoform X13

    Conserved Domains (1) summary
    cl17171
    Location:42114
    PH-like; Pleckstrin homology-like domain
  16. XM_024448105.1XP_024303873.1  rho GTPase-activating protein 22 isoform X15

    Conserved Domains (1) summary
    cl17171
    Location:42116
    PH-like; Pleckstrin homology-like domain
  17. XM_024448102.1XP_024303870.1  rho GTPase-activating protein 22 isoform X12

    Conserved Domains (1) summary
    cl17171
    Location:42130
    PH-like; Pleckstrin homology-like domain
  18. XM_024448104.1XP_024303872.1  rho GTPase-activating protein 22 isoform X14

    Conserved Domains (1) summary
    cl17171
    Location:42114
    PH-like; Pleckstrin homology-like domain
  19. XM_024448106.1XP_024303874.1  rho GTPase-activating protein 22 isoform X16

    Conserved Domains (1) summary
    cl17171
    Location:4284
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_002957001.1 RNA Sequence

  2. XR_002957004.1 RNA Sequence

  3. XR_002957000.1 RNA Sequence

  4. XR_001747166.2 RNA Sequence

  5. XR_002956998.1 RNA Sequence

  6. XR_002956999.1 RNA Sequence

  7. XR_002957003.1 RNA Sequence

  8. XR_002957002.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256027.1: Suppressed sequence

    Description
    NM_001256027.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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