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OPRPN opiorphin prepropeptide [ Homo sapiens (human) ]

Gene ID: 58503, updated on 11-May-2025
Official Symbol
OPRPNprovided by HGNC
Official Full Name
opiorphin prepropeptideprovided by HGNC
Primary source
HGNC:HGNC:17279
See related
Ensembl:ENSG00000171199 MIM:608936; AllianceGenome:HGNC:17279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPLP; PRL1; PROL1; opiorphin
Summary
This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward salivary gland (RPKM 9.7) See more
Orthologs
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See OPRPN in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70397940..70410195)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73737473..73749728)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71263657..71275912)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene submaxillary gland androgen regulated protein 3B Neighboring gene mucin 7, secreted Neighboring gene amelotin

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
Preferred Names
opiorphin prepropeptide
Names
basic proline-rich lacrimal protein
basic proline-rich protein
proline rich, lacrimal 1
proline-rich 1
proline-rich protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302807.2NP_001289736.1  opiorphin prepropeptide isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) lacks the functional QRFSR pentapeptide, known as opiorphin, located in the N-terminal of isoform 1.
    Source sequence(s)
    CD721906, CD722615, CD723077
    Conserved Domains (2) summary
    pfam14124
    Location:155
    DUF4291; Domain of unknown function (DUF4291)
    pfam15621
    Location:118
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
  2. NM_021225.5NP_067048.4  opiorphin prepropeptide isoform 1 precursor

    See identical proteins and their annotated locations for NP_067048.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC092438, CK430664
    Consensus CDS
    CCDS43235.1
    UniProtKB/Swiss-Prot
    A8MZ07, P85047, Q99935
    Related
    ENSP00000382485.2, ENST00000399575.7
    Conserved Domains (1) summary
    pfam15621
    Location:396
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RNA

  1. NR_126503.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    CD721906, CD722615, CK429697

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    70397940..70410195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73737473..73749728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)