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OPRPN opiorphin prepropeptide [ Homo sapiens (human) ]

Gene ID: 58503, updated on 24-Nov-2020

Summary

Official Symbol
OPRPNprovided by HGNC
Official Full Name
opiorphin prepropeptideprovided by HGNC
Primary source
HGNC:HGNC:17279
See related
Ensembl:ENSG00000171199 MIM:608936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPLP; PRL1; PROL1; opiorphin
Summary
This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward salivary gland (RPKM 9.7) See more
Orthologs

Genomic context

See OPRPN in Genome Data Viewer
Location:
4q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (70397940..70410195)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71263599..71275914)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene submaxillary gland androgen regulated protein 3B Neighboring gene mucin 7, secreted Neighboring gene amelotin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
retina homeostasis HEP PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 

General protein information

Preferred Names
opiorphin prepropeptide
Names
basic proline-rich lacrimal protein
basic proline-rich protein
proline rich, lacrimal 1
proline-rich 1
proline-rich protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302807.2NP_001289736.1  opiorphin prepropeptide isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) lacks the functional QRFSR pentapeptide, known as opiorphin, located in the N-terminal of isoform 1.
    Source sequence(s)
    CD721906, CD722615, CD723077
    Conserved Domains (2) summary
    pfam14124
    Location:155
    DUF4291; Domain of unknown function (DUF4291)
    pfam15621
    Location:118
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
  2. NM_021225.5NP_067048.4  opiorphin prepropeptide isoform 1 precursor

    See identical proteins and their annotated locations for NP_067048.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC092438, CK430664
    Consensus CDS
    CCDS43235.1
    UniProtKB/Swiss-Prot
    Q99935
    Related
    ENSP00000382485.2, ENST00000399575.7
    Conserved Domains (1) summary
    pfam15621
    Location:396
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RNA

  1. NR_126503.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    CD721906, CD722615, CK429697

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    70397940..70410195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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