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MYL7 myosin light chain 7 [ Homo sapiens (human) ]

Gene ID: 58498, updated on 24-Nov-2020

Summary

Official Symbol
MYL7provided by HGNC
Official Full Name
myosin light chain 7provided by HGNC
Primary source
HGNC:HGNC:21719
See related
Ensembl:ENSG00000106631 MIM:613993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYL2A; MYLC2A
Expression
Restricted expression toward heart (RPKM 2260.5) See more
Orthologs

Genomic context

See MYL7 in Genome Data Viewer
Location:
7p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44138864..44141392, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44178463..44180974, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DNA polymerase delta 2, accessory subunit Neighboring gene RNA, 5S ribosomal pseudogene 230 Neighboring gene uncharacterized LOC105375258 Neighboring gene glucokinase Neighboring gene uncharacterized LOC105375257

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Treatment of human brain endothelial cells with Tat markedly elevates GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
muscle contraction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
A band IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
myosin complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myosin regulatory light chain 2, atrial isoform
Names
MLC-2a
MLC2a
myosin light chain 2a
myosin regulatory light chain 7
myosin, light chain 7, regulatory
myosin, light polypeptide 7, regulatory

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021223.3NP_067046.1  myosin regulatory light chain 2, atrial isoform

    See identical proteins and their annotated locations for NP_067046.1

    Status: VALIDATED

    Source sequence(s)
    AC006454, BC027915, W17098
    Consensus CDS
    CCDS5478.1
    UniProtKB/Swiss-Prot
    Q01449
    Related
    ENSP00000223364.3, ENST00000223364.7
    Conserved Domains (1) summary
    PTZ00184
    Location:28168
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44138864..44141392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515463.2XP_011513765.1  myosin regulatory light chain 2, atrial isoform isoform X1

    Conserved Domains (2) summary
    pfam13499
    Location:62154
    EF-hand_7; EF-hand domain pair
    pfam13833
    Location:72157
    EF-hand_8; EF-hand domain pair
  2. XM_011515464.2XP_011513766.1  myosin regulatory light chain 2, atrial isoform isoform X2

    See identical proteins and their annotated locations for XP_011513766.1

    Conserved Domains (1) summary
    PTZ00184
    Location:28143
    PTZ00184; calmodulin; Provisional
  3. XM_005249817.4XP_005249874.1  myosin regulatory light chain 2, atrial isoform isoform X5

    Conserved Domains (2) summary
    PTZ00184
    Location:28149
    PTZ00184; calmodulin; Provisional
    pfam13833
    Location:72117
    EF-hand_8; EF-hand domain pair
  4. XM_024446851.1XP_024302619.1  myosin regulatory light chain 2, atrial isoform isoform X3

    Related
    ENSP00000389202.1, ENST00000457314.5
    Conserved Domains (1) summary
    cl25352
    Location:28191
    EFh_PEF; The penta-EF hand (PEF) family
  5. XM_017012479.1XP_016867968.1  myosin regulatory light chain 2, atrial isoform isoform X7

  6. XM_011515465.2XP_011513767.1  myosin regulatory light chain 2, atrial isoform isoform X4

    See identical proteins and their annotated locations for XP_011513767.1

    Related
    ENST00000434895.5
    Conserved Domains (1) summary
    cl08302
    Location:3694
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  7. XM_017012478.1XP_016867967.1  myosin regulatory light chain 2, atrial isoform isoform X6

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