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JAM2 junctional adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 58494, updated on 12-Sep-2017
Official Symbol
JAM2provided by HGNC
Official Full Name
junctional adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:14686
See related
Ensembl:ENSG00000154721 MIM:606870; Vega:OTTHUMG00000078441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAMB; CD322; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43
Summary
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Orthologs
Location:
21q21.3
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (25639282..25717562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27011594..27089874)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 515 Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene 1 Neighboring gene ferredoxin 1 pseudogene 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 Neighboring gene GA binding protein transcription factor alpha subunit Neighboring gene LLP homolog, long-term synaptic facilitation pseudogene 2

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 JRFL and HXB2 (gp120) downregulates JAM2 in ARPE-19 cells and is dependent upon MMP activation PubMed
env The expression of tight junction proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5 is modulated by HIV-1 gp120, and the modulated TJ expression involves Rho-A activation PubMed
Tat tat HIV-1 Tat in combination with morphine can upregulate JAM-2 expression in primary brain micro vascular endothelial cells PubMed
tat HIV-1 Tat B disrupts blood-brain barrier (BBB) integrity to a greater extent compared to HIV-1 Tat C. This BBB dysfunction is associated with modulated expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2 PubMed

Go to the HIV-1, Human Interaction Database

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
    Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
junctional adhesion molecule B
Names
JAM-2
JAM-IT/VE-JAM
vascular endothelial junction-associated molecule

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270407.1NP_001257336.1  junctional adhesion molecule B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AI742752, AK056079, AK294769, BG540412, BM921497, CX870550
    Consensus CDS
    CCDS58788.1
    UniProtKB/Swiss-Prot
    P57087
    Related
    ENSP00000318416.6, ENST00000312957.9
    Conserved Domains (3) summary
    smart00408
    Location:111185
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:3594
    IG_like; Immunoglobulin like
    cl11960
    Location:1894
    Ig; Immunoglobulin domain
  2. NM_001270408.1NP_001257337.1  junctional adhesion molecule B isoform 3 precursor

    See identical proteins and their annotated locations for NP_001257337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1, which results in a frame-shift, and a longer isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AY358361, BM921497
    Consensus CDS
    CCDS58787.1
    UniProtKB/Swiss-Prot
    P57087
    Related
    ENSP00000383376.1, OTTHUMP00000096102, ENST00000400532.5, OTTHUMT00000171349
    Conserved Domains (3) summary
    smart00408
    Location:147221
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:35130
    IG_like; Immunoglobulin like
    cl11960
    Location:37131
    Ig; Immunoglobulin domain
  3. NM_021219.3NP_067042.1  junctional adhesion molecule B isoform 1 precursor

    See identical proteins and their annotated locations for NP_067042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AI742752, AK056079, AK294769, AY077698, BG540412, BM921497, CX870550
    Consensus CDS
    CCDS42911.1
    UniProtKB/Swiss-Prot
    P57087
    Related
    ENSP00000420419.1, OTTHUMP00000096100, ENST00000480456.5, OTTHUMT00000171347
    Conserved Domains (2) summary
    smart00410
    Location:35130
    IG_like; Immunoglobulin like
    cd00096
    Location:151225
    Ig; Immunoglobulin domain

RNA

  1. NR_072999.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate donor splice site at an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI742752, AK056079, AK294769, AX772824, BG540412, BM921497, CX870550

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

    Range
    25639282..25717562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_937537.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    26572234..26650529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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