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INIP INTS3 and NABP interacting protein [ Homo sapiens (human) ]

Gene ID: 58493, updated on 7-Jun-2020

Summary

Official Symbol
INIPprovided by HGNC
Official Full Name
INTS3 and NABP interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:24994
See related
Ensembl:ENSG00000148153 MIM:613273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1
Summary
The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in lymph node (RPKM 8.2), colon (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See INIP in Genome Data Viewer
Location:
9q32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (112683926..112718117, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115448786..115480387, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene hydroxysteroid dehydrogenase like 2 Neighboring gene chromosome 9 open reading frame 147 Neighboring gene KIAA1958 Neighboring gene uncharacterized LOC107987117 Neighboring gene sorting nexin family member 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SOSS complex subunit C
Names
SSB-interacting protein 1
hSSB-interacting protein 1
minute INTS3/hSSB-associated element
sensor of single-strand DNA complex subunit C
sensor of ssDNA subunit C
single-stranded DNA-binding protein-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329585.2NP_001316514.1  SOSS complex subunit C isoform b

    Status: REVIEWED

    Source sequence(s)
    AL390067
    Conserved Domains (1) summary
    pfam15925
    Location:1598
    SOSSC; SOSS complex subunit C
  2. NM_001329586.2NP_001316515.1  SOSS complex subunit C isoform c

    Status: REVIEWED

    Source sequence(s)
    AL390067
  3. NM_001329587.2NP_001316516.1  SOSS complex subunit C isoform d

    Status: REVIEWED

    Source sequence(s)
    AL390067
  4. NM_001329588.2NP_001316517.1  SOSS complex subunit C isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform e.
    Source sequence(s)
    AL390067
    Consensus CDS
    CCDS87676.1
    UniProtKB/TrEMBL
    X6R8P6
    Conserved Domains (1) summary
    pfam15925
    Location:371
    SOSSC; SOSS complex subunit C
  5. NM_001329589.2NP_001316518.1  SOSS complex subunit C isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform e.
    Source sequence(s)
    AL390067
    Consensus CDS
    CCDS87676.1
    UniProtKB/TrEMBL
    X6R8P6
    Related
    ENSP00000363353.1, ENST00000374236.5
    Conserved Domains (1) summary
    pfam15925
    Location:371
    SOSSC; SOSS complex subunit C
  6. NM_001329590.2NP_001316519.1  SOSS complex subunit C isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform e.
    Source sequence(s)
    AL390067
    Consensus CDS
    CCDS87676.1
    UniProtKB/TrEMBL
    X6R8P6
    Conserved Domains (1) summary
    pfam15925
    Location:371
    SOSSC; SOSS complex subunit C
  7. NM_021218.3NP_067041.1  SOSS complex subunit C isoform a

    See identical proteins and their annotated locations for NP_067041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL390067, BC065210, BQ219222
    Consensus CDS
    CCDS6785.1
    UniProtKB/Swiss-Prot
    Q9NRY2
    Related
    ENSP00000363360.3, ENST00000374242.9
    Conserved Domains (1) summary
    pfam15925
    Location:18101
    SOSSC; SOSS complex subunit C

RNA

  1. NR_138054.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL390067
  2. NR_138055.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL390067
  3. NR_138056.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL390067

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    112683926..112718117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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