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PCTP phosphatidylcholine transfer protein [ Homo sapiens (human) ]

Gene ID: 58488, updated on 7-Jun-2020

Summary

Official Symbol
PCTPprovided by HGNC
Official Full Name
phosphatidylcholine transfer proteinprovided by HGNC
Primary source
HGNC:HGNC:8752
See related
Ensembl:ENSG00000141179 MIM:606055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC-TP; STARD2
Expression
Ubiquitous expression in liver (RPKM 9.3), placenta (RPKM 5.2) and 24 other tissues See more
Orthologs

Genomic context

See PCTP in Genome Data Viewer
Location:
17q22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (55750979..55845001)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (53828340..53920522)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.3823 Neighboring gene transmembrane protein 100 Neighboring gene ankyrin repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC112268194

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphatidylcholine transfer protein (PCTP) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine transporter activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid transport NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
phosphatidylcholine transfer protein
Names
START domain-containing protein 2
StAR-related lipid transfer (START) domain containing 2
stAR-related lipid transfer protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102402.2NP_001095872.1  phosphatidylcholine transfer protein isoform 2

    See identical proteins and their annotated locations for NP_001095872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC009837, AC091155, AK058120, BC012084, BM549250, BX648199
    Consensus CDS
    CCDS45741.1
    UniProtKB/Swiss-Prot
    Q9UKL6
    Related
    ENSP00000325181.5, ENST00000325214.10
    Conserved Domains (1) summary
    cl14643
    Location:1138
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_001330377.2NP_001317306.1  phosphatidylcholine transfer protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009837, AC091155
    Consensus CDS
    CCDS82165.1
    UniProtKB/TrEMBL
    I3L2M9
    Related
    ENSP00000459793.1, ENST00000576183.5
    Conserved Domains (1) summary
    cl14643
    Location:4195
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. NM_001330378.2NP_001317307.1  phosphatidylcholine transfer protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF151638, AW298344, AW369326, BE245218, BM907258
    Consensus CDS
    CCDS82166.1
    UniProtKB/Swiss-Prot
    Q9UKL6
    UniProtKB/TrEMBL
    I3L3H0
    Related
    ENSP00000460437.1, ENST00000573500.5
    Conserved Domains (1) summary
    cd08910
    Location:4194
    START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins
  4. NM_021213.4NP_067036.2  phosphatidylcholine transfer protein isoform 1

    See identical proteins and their annotated locations for NP_067036.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009837, AC091155, BC012084, BM153142, BX648199
    Consensus CDS
    CCDS11588.1
    UniProtKB/Swiss-Prot
    Q9UKL6
    UniProtKB/TrEMBL
    Q549N3
    Related
    ENSP00000268896.4, ENST00000268896.10
    Conserved Domains (1) summary
    cd08910
    Location:4210
    START_STARD2-like; Lipid-binding START domain of mammalian STARD2 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    55750979..55845001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024913.1XP_016880402.1  phosphatidylcholine transfer protein isoform X1

RNA

  1. XR_243677.4 RNA Sequence

  2. XR_001752577.1 RNA Sequence

    Related
    ENST00000417982.6
  3. XR_001752576.1 RNA Sequence

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