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CREBZF CREB/ATF bZIP transcription factor [ Homo sapiens (human) ]

Gene ID: 58487, updated on 9-Feb-2020

Summary

Official Symbol
CREBZFprovided by HGNC
Official Full Name
CREB/ATF bZIP transcription factorprovided by HGNC
Primary source
HGNC:HGNC:24905
See related
Ensembl:ENSG00000137504 MIM:606444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF; SMILE
Expression
Ubiquitous expression in endometrium (RPKM 18.3), spleen (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See CREBZF in Genome Data Viewer
Location:
11q14.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (85657564..85665148, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (85368608..85376182, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 126B Neighboring gene transmembrane protein 126A Neighboring gene coiled-coil domain containing 89 Neighboring gene synaptotagmin like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ94018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CREB/ATF bZIP transcription factor
Names
HCF-binding transcription factor Zhangfei
SHP-interacting leucine zipper protein
Zhangfei
host cell factor-binding transcription factor Zhangfei

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039618.4NP_001034707.1  CREB/ATF bZIP transcription factor

    See identical proteins and their annotated locations for NP_001034707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AP000642
    Consensus CDS
    CCDS41697.1
    UniProtKB/Swiss-Prot
    Q9NS37
    Related
    ENSP00000433459.1, ENST00000527447.1
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

  1. NR_028024.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642
  2. NR_028025.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642
  3. NR_028026.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642
  4. NR_028027.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP000642
  5. NR_165399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  6. NR_165400.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642, KF511165
  7. NR_165401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642, KF511165
  8. NR_165402.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  9. NR_165403.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  10. NR_165404.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  11. NR_165405.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  12. NR_165406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  13. NR_165407.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  14. NR_165408.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  15. NR_165409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  16. NR_165410.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642
  17. NR_165411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP000642

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    85657564..85665148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018087.1XP_016873576.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  2. XM_017018091.1XP_016873580.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  3. XM_017018092.1XP_016873581.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  4. XM_017018089.1XP_016873578.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  5. XM_017018086.1XP_016873575.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Related
    ENSP00000435762.1, ENST00000525639.1
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  6. XM_006718642.3XP_006718705.1  CREB/ATF bZIP transcription factor isoform X1

    UniProtKB/TrEMBL
    E9PIM0
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  7. XM_017018090.1XP_016873579.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NS37
    Related
    ENSP00000434281.1, ENST00000490820.2
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  8. XM_011545195.2XP_011543497.1  CREB/ATF bZIP transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011543497.1

    UniProtKB/Swiss-Prot
    Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
  9. XM_017018088.1XP_016873577.1  CREB/ATF bZIP transcription factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NS37
    Conserved Domains (1) summary
    cl21462
    Location:219260
    bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_021212.1: Suppressed sequence

    Description
    NM_021212.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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