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ZBED5 zinc finger BED-type containing 5 [ Homo sapiens (human) ]

Gene ID: 58486, updated on 1-Jun-2020

Summary

Official Symbol
ZBED5provided by HGNC
Official Full Name
zinc finger BED-type containing 5provided by HGNC
Primary source
HGNC:HGNC:30803
See related
Ensembl:ENSG00000236287 MIM:615251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Buster1
Summary
This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in lymph node (RPKM 23.1), endometrium (RPKM 21.4) and 25 other tissues See more
Orthologs

Genomic context

See ZBED5 in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (10852706..10858053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10874251..10879620, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928053 Neighboring gene uncharacterized LOC112268072 Neighboring gene uncharacterized LOC105376547 Neighboring gene ZBED5 antisense RNA 1 Neighboring gene uncharacterized LOC107984309

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger, BED-type containing 5 (ZBED5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: EIF4G2

Homology

Clone Names

  • FLJ41239, FLJ44349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
zinc finger BED domain-containing protein 5
Names
transposon-derived Buster1 transposase-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143667.2NP_001137139.1  zinc finger BED domain-containing protein 5

    See identical proteins and their annotated locations for NP_001137139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK315033, BQ028130, DA785416
    UniProtKB/Swiss-Prot
    Q49AG3
    Related
    ENSP00000415939.2, ENST00000413761.7
    Conserved Domains (1) summary
    smart00614
    Location:117160
    ZnF_BED; BED zinc finger
  2. NM_021211.4NP_067034.2  zinc finger BED domain-containing protein 5

    See identical proteins and their annotated locations for NP_067034.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF205600, AK315033, BQ028130, DA785416
    UniProtKB/Swiss-Prot
    Q49AG3
    Related
    ENSP00000398106.2, ENST00000432999.6
    Conserved Domains (1) summary
    smart00614
    Location:117160
    ZnF_BED; BED zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    10852706..10858053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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