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ENOPH1 enolase-phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 58478, updated on 12-Sep-2021

Summary

Official Symbol
ENOPH1provided by HGNC
Official Full Name
enolase-phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:24599
See related
Ensembl:ENSG00000145293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E1; MASA; mtnC; MST145
Expression
Ubiquitous expression in brain (RPKM 34.5), thyroid (RPKM 16.6) and 25 other tissues See more
Orthologs
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Genomic context

See ENOPH1 in Genome Data Viewer
Location:
4q21.22
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (82430590..82461177)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83351743..83382330)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 4 Neighboring gene heterogeneous nuclear ribonucleoprotein D like Neighboring gene syncytin-1-like Neighboring gene transmembrane protein 150C Neighboring gene ribosomal protein L7a pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12594, DKFZp586M0524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
Inferred from Electronic Annotation
more info
 
enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables acireductone synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acireductone synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-methionine salvage from S-adenosylmethionine IEA
Inferred from Electronic Annotation
more info
 
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-methionine salvage from methylthioadenosine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
enolase-phosphatase E1
Names
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
acireductone synthase
NP_001278946.1
NP_067027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292017.2NP_001278946.1  enolase-phosphatase E1 isoform 2

    See identical proteins and their annotated locations for NP_001278946.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC067942, AL518796, AW470971, BC065815, CN335976, DA067292
    Consensus CDS
    CCDS75154.1
    UniProtKB/Swiss-Prot
    Q9UHY7
    UniProtKB/TrEMBL
    D6RA00
    Related
    ENSP00000422005.1, ENST00000509635.5
    Conserved Domains (1) summary
    cd01629
    Location:1146
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep
  2. NM_021204.5NP_067027.1  enolase-phosphatase E1 isoform 1

    See identical proteins and their annotated locations for NP_067027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC067942, AW470971, BC065815, DA067292
    Consensus CDS
    CCDS3594.1
    UniProtKB/Swiss-Prot
    Q9UHY7
    Related
    ENSP00000273920.3, ENST00000273920.8
    Conserved Domains (1) summary
    cd01629
    Location:12234
    HAD_EP; Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep

RNA

  1. NR_120457.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC067942, AW470971, BC001317, DA067292
    Related
    ENST00000505846.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    82430590..82461177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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