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TP53INP2 tumor protein p53 inducible nuclear protein 2 [ Homo sapiens (human) ]

Gene ID: 58476, updated on 5-Mar-2024

Summary

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Official Symbol
TP53INP2provided by HGNC
Official Full Name
tumor protein p53 inducible nuclear protein 2provided by HGNC
Primary source
HGNC:HGNC:16104
See related
Ensembl:ENSG00000078804 MIM:617549; AllianceGenome:HGNC:16104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1
Summary
The protein encoded by this gene promotes autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
20q11.22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34704344..34713436)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36425010..36434099)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33292148..33301240)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33153261-33153762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33170999-33171500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33171501-33172000 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class U Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33264364-33265250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33265251-33266136 Neighboring gene uncharacterized LOC105372599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12843 Neighboring gene Sharpr-MPRA regulatory region 13945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12846 Neighboring gene nuclear receptor coactivator 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The bifunctional role of TP53INP2 in transcription and autophagy. Xu Y, et al. Autophagy, 2020 Jul. PMID 31931658, Free PMC Article
  2. TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells. Hu Y, et al. Biomed Pharmacother, 2017 Apr. PMID 28131096
  3. TP53INP2/DOR protein chaperones deacetylated nuclear LC3 to the cytoplasm to promote macroautophagy. Liu X, et al. Autophagy, 2015. PMID 26213321, Free PMC Article
  4. The combination of TP53INP1, TP53INP2 and AXIN2: potential biomarkers in papillary thyroid carcinoma. He M, et al. Endocrine, 2015 Mar. PMID 25104271
  5. DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus. Mauvezin C, et al. FEBS Lett, 2012 Sep 21. PMID 22750142

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TP53INP2 modulates the malignant progression of colorectal cancer by reducing the inactive form of beta-catenin.
    Title: TP53INP2 modulates the malignant progression of colorectal cancer by reducing the inactive form of β-catenin.
  2. Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells.
    Title: Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells.
  3. Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
    Title: Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
  4. TP53INP2 Contributes to TGF-beta2-Induced Autophagy during the Epithelial-Mesenchymal Transition in Posterior Capsular Opacification Development.
    Title: TP53INP2 Contributes to TGF-β2-Induced Autophagy during the Epithelial-Mesenchymal Transition in Posterior Capsular Opacification Development.
  5. Overexpression of TP53INP2 Promotes Apoptosis in Clear Cell Renal Cell Cancer via Caspase-8/TRAF6 Signaling Pathway.
    Title: Overexpression of TP53INP2 Promotes Apoptosis in Clear Cell Renal Cell Cancer via Caspase-8/TRAF6 Signaling Pathway.
  6. Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.
    Title: Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury.
  7. The bifunctional role of TP53INP2 in transcription and autophagy.
    Title: The bifunctional role of TP53INP2 in transcription and autophagy.
  8. TP53INP2 interacted directly with ATG7 to form a LC3B-TP53INP2-ATG7 complex in the cytoplasm.
    Title: TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.
  9. Results showed that TP53INP2 interacts with ubiquitin and ubiquitinated proteins through the ubiquitin-interacting motif (UIM). Moreover, overexpression of TP53INP2 lacking the UIM in cells leads to massive accumulation of ubiquitinated proteins and sensitizes the cells to apoptosis under stressed conditions.
    Title: TP53INP2 mediates autophagic degradation of ubiquitinated proteins through its ubiquitin-interacting motif.
  10. A screen of cancer cell lines showed that those with higher protein levels of TP53INP2 are more prone to TRAIL-induced apoptosis, making TP53INP2 a potential predictive marker of cancer cell responsiveness to TRAIL treatment. These findings uncover a novel mechanism for the regulation of caspase-8 ubiquitination and reveal TP53INP2 as an important regulator of the death receptor pathway.
    Title: Regulation of death receptor signaling by the autophagy protein TP53INP2.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21759, FLJ23500, DKFZp434B2411, DKFZp434O0827

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor protein p53-inducible nuclear protein 2
Names
diabetes and obesity-regulated
p53-inducible protein U

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329429.2 → NP_001316358.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, DB479841
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Conserved Domains (1) summary
    pfam14839
    Location:67 → 211
    DOR; DOR family

  2. NM_001329430.2 → NP_001316359.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159, HY150218
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Related
    ENSP00000363942.2, ENST00000374809.6
    Conserved Domains (1) summary
    pfam14839
    Location:67 → 211
    DOR; DOR family

  3. NM_001329431.2 → NP_001316360.1  tumor protein p53-inducible nuclear protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL109824, AY422170, CA310159, HY157843
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Conserved Domains (1) summary
    pfam14839
    Location:67 → 211
    DOR; DOR family

  4. NM_021202.3 → NP_067025.1  tumor protein p53-inducible nuclear protein 2

    See identical proteins and their annotated locations for NP_067025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1). All four variants encode the same protein.
    Source sequence(s)
    AY422170, CA310159
    Consensus CDS
    CCDS13240.1
    UniProtKB/Swiss-Prot
    A8K8S8, E1P5P6, Q5JX64, Q8IXH6, Q8IYL5, Q9NU00
    Related
    ENSP00000363943.3, ENST00000374810.8
    Conserved Domains (1) summary
    pfam14839
    Location:67 → 211
    DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    34704344..34713436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    36425010..36434099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXH6.2 GenPept UniProtKB/Swiss-Prot:Q8IXH6

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