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MS4A7 membrane spanning 4-domains A7 [ Homo sapiens (human) ]

Gene ID: 58475, updated on 13-Mar-2020

Summary

Official Symbol
MS4A7provided by HGNC
Official Full Name
membrane spanning 4-domains A7provided by HGNC
Primary source
HGNC:HGNC:13378
See related
Ensembl:ENSG00000166927 MIM:606502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFFM4; MS4A8; 4SPAN2; CD20L4
Summary
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 76.0), lung (RPKM 24.9) and 15 other tissues See more
Orthologs

Genomic context

See MS4A7 in Genome Data Viewer
Location:
11q12.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60378485..60395954)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60145949..60163427)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A4A Neighboring gene membrane spanning 4-domains A6E Neighboring gene membrane spanning 4-domains A14 Neighboring gene membrane spanning 4-domains A5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MS4A14

Homology

Clone Names

  • MGC22368

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 7
Names
CD20 antigen-like 4
CD20/Fc-epsilon-RI-beta family member 4
four-span transmembrane protein 2
high affinity immunoglobulin epsilon receptor beta subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021201.5NP_067024.1  membrane-spanning 4-domains subfamily A member 7 isoform 1

    See identical proteins and their annotated locations for NP_067024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. It encodes the longer isoform (1).
    Source sequence(s)
    AK075106, AV685115, AV690480, BC020673, CA449361, CD518120
    Consensus CDS
    CCDS7985.1
    UniProtKB/Swiss-Prot
    Q9GZW8
    UniProtKB/TrEMBL
    A0A024R556
    Related
    ENSP00000300184.3, ENST00000300184.8
    Conserved Domains (1) summary
    pfam04103
    Location:47207
    CD20; CD20-like family
  2. NM_206938.1NP_996821.1  membrane-spanning 4-domains subfamily A member 7 isoform 2

    See identical proteins and their annotated locations for NP_996821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AK075106, AV685115, AV690480, CA449361, CD518120
    Consensus CDS
    CCDS7986.1
    UniProtKB/Swiss-Prot
    Q9GZW8
    UniProtKB/TrEMBL
    A0A024R505
    Related
    ENSP00000350983.1, ENST00000358246.5
    Conserved Domains (1) summary
    pfam04103
    Location:50162
    CD20; CD20-like family
  3. NM_206939.2NP_996822.1  membrane-spanning 4-domains subfamily A member 7 isoform 1

    See identical proteins and their annotated locations for NP_996822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternative splice site for the first exon compared to variant 1. Both variants 3 and 1 encode the same isoform (1).
    Source sequence(s)
    AK075106, AV685115, AV690480, CA449361, CD518120, CD706728
    Consensus CDS
    CCDS7985.1
    UniProtKB/Swiss-Prot
    Q9GZW8
    UniProtKB/TrEMBL
    A0A024R556
    Conserved Domains (1) summary
    pfam04103
    Location:47207
    CD20; CD20-like family
  4. NM_206940.2NP_996823.1  membrane-spanning 4-domains subfamily A member 7 isoform 2

    See identical proteins and their annotated locations for NP_996823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site for the first exon and lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1. Variants 4 and 2 encode the same isoform (2).
    Source sequence(s)
    AK075106, AV685115, AV690480, CA449361, CD518120, CD706728
    Consensus CDS
    CCDS7986.1
    UniProtKB/Swiss-Prot
    Q9GZW8
    UniProtKB/TrEMBL
    A0A024R505
    Related
    ENSP00000434637.1, ENST00000534016.5
    Conserved Domains (1) summary
    pfam04103
    Location:50162
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60378485..60395954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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