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PXMP2 peroxisomal membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 5827, updated on 8-Dec-2022

Summary

Official Symbol
PXMP2provided by HGNC
Official Full Name
peroxisomal membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:9716
See related
Ensembl:ENSG00000176894 MIM:617399; AllianceGenome:HGNC:9716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PMP22; MPV17L3
Summary
Located in peroxisomal membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 47.9), kidney (RPKM 25.6) and 25 other tissues See more
Orthologs
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Genomic context

See PXMP2 in Genome Data Viewer
Location:
12q24.33
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132687587..132704985)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (132737814..132753863)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133264173..133281571)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 2 Neighboring gene DNA polymerase epsilon, catalytic subunit Neighboring gene uncharacterized LOC124903063 Neighboring gene PGAM family member 5, mitochondrial serine/threonine protein phosphatase Neighboring gene RNA, 5S ribosomal pseudogene 379

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PGAM5

Homology

Clone Names

  • FLJ54922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal membrane protein 2
Names
22 kDa peroxisomal membrane protein
peroxisomal membrane protein 2, 22kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018663.3NP_061133.1  peroxisomal membrane protein 2

    See identical proteins and their annotated locations for NP_061133.1

    Status: VALIDATED

    Source sequence(s)
    AC135586, AF250136, BC073997
    Consensus CDS
    CCDS9279.1
    UniProtKB/Swiss-Prot
    Q9NR77
    Related
    ENSP00000321271.3, ENST00000317479.8
    Conserved Domains (1) summary
    pfam04117
    Location:131193
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132687587..132704985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    132737814..132753863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)