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Nudt11 nudix hydrolase 11 [ Mus musculus (house mouse) ]

Gene ID: 58242, updated on 30-Apr-2024

Summary

Official Symbol
Nudt11provided by MGI
Official Full Name
nudix hydrolase 11provided by MGI
Primary source
MGI:MGI:1930957
See related
Ensembl:ENSMUSG00000073295 AllianceGenome:MGI:1930957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIPP3; DIPP3b; Dipp3a; Nudt10
Summary
Enables diphosphoinositol-polyphosphate diphosphatase activity. Predicted to be involved in diphosphoinositol polyphosphate metabolic process and nucleotide catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; lung; metanephros; and tooth. Orthologous to several human genes including NUDT11 (nudix hydrolase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.1) and 11 other tissues See more
Orthologs
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Genomic context

See Nudt11 in Genome Data Viewer
Location:
X A1.1; X 2.68 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (5959488..5966805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6047471..6054751)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 51614 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46652 Neighboring gene predicted gene 14450 Neighboring gene predicted gene, 26618 Neighboring gene STARR-seq mESC enhancer starr_46653 Neighboring gene ribosomal protein L19, pseudogene 12 Neighboring gene EZH inhibitory protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables bis(5'-adenosyl)-pentaphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diphosphoinositol-polyphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diphosphoinositol-polyphosphate diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diadenosine hexaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diadenosine pentaphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diphosphoinositol polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
diphosphoinositol polyphosphate phosphohydrolase 3-beta
Names
DIPP-3-alpha
DIPP-3-beta
DIPP3-alpha
DIPP3-beta
Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Nucleoside diphosphate-linked moiety X motif 10
Nudix motif 10
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
diadenosine hexaphosphate hydrolase (AMP-forming)
nucleoside diphosphate-linked moiety X motif 11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
nudix motif 11
nudix-type motif 11
NP_067406.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021431.2NP_067406.2  diphosphoinositol polyphosphate phosphohydrolase 3-beta

    See identical proteins and their annotated locations for NP_067406.2

    Status: VALIDATED

    Source sequence(s)
    BC071274, BX465866
    Consensus CDS
    CCDS29955.1
    UniProtKB/Swiss-Prot
    P0C027, P0C028, Q8BKF4, Q9JJD3
    Related
    ENSMUSP00000100072.4, ENSMUST00000103007.4
    Conserved Domains (1) summary
    cd04666
    Location:18137
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    5959488..5966805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003953019.2 RNA Sequence