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Pard6b par-6 family cell polarity regulator beta [ Mus musculus (house mouse) ]

Gene ID: 58220, updated on 10-Jan-2023

Summary

Official Symbol
Pard6bprovided by MGI
Official Full Name
par-6 family cell polarity regulator betaprovided by MGI
Primary source
MGI:MGI:2135605
See related
Ensembl:ENSMUSG00000044641 AllianceGenome:MGI:2135605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Par6b
Summary
Predicted to enable protein kinase C binding activity. Predicted to be involved in several processes, including centrosome cycle; establishment or maintenance of cell polarity; and protein-containing complex assembly. Predicted to act upstream of or within cell division. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and cell cortex. Is expressed in blastocyst; early conceptus; egg cylinder; and lung epithelium. Orthologous to human PARD6B (par-6 family cell polarity regulator beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 10.3), kidney adult (RPKM 8.3) and 23 other tissues See more
Orthologs
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Genomic context

See Pard6b in Genome Data Viewer
Location:
2; 2 H3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167922924..167943123)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168081004..168101203)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33108 Neighboring gene predicted gene, 39990 Neighboring gene predicted gene, 46787 Neighboring gene predicted gene, 39991

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
partitioning defective 6 homolog beta
Names
PAR-6 beta
PAR-6B
par-6 (partitioning defective 6) homolog beta
partitioning-defective protein 6, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021409.2NP_067384.2  partitioning defective 6 homolog beta

    See identical proteins and their annotated locations for NP_067384.2

    Status: VALIDATED

    Source sequence(s)
    AI837082, AL831766, CJ050007, CJ062867, CX568497
    Consensus CDS
    CCDS17108.1
    UniProtKB/Swiss-Prot
    Q8R3J8, Q9JK83
    Related
    ENSMUSP00000052619.7, ENSMUST00000052125.7
    Conserved Domains (2) summary
    cd06403
    Location:1796
    PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...
    cd00992
    Location:156247
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    167922924..167943123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)