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Bcl11b B cell leukemia/lymphoma 11B [ Mus musculus (house mouse) ]

Gene ID: 58208, updated on 25-Nov-2021

Summary

Official Symbol
Bcl11bprovided by MGI
Official Full Name
B cell leukemia/lymphoma 11Bprovided by MGI
Primary source
MGI:MGI:1929913
See related
Ensembl:ENSMUSG00000048251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rit1; Ctip2; BCL-11B; AI604821; 9130430L19Rik; B630002E05Rik
Expression
Biased expression in thymus adult (RPKM 56.0), CNS E18 (RPKM 12.1) and 8 other tissues See more
Orthologs
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Genomic context

See Bcl11b in Genome Data Viewer
Location:
12 F1; 12 59.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (107876662..107970404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (107910403..108004145, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109148613..109241624, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930465M20 gene Neighboring gene predicted gene, 33341 Neighboring gene SET domain containing 3 Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell receptor V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within keratinocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphoid lineage cell migration into thymus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory bulb axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striatal medium spiny neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
B-cell lymphoma/leukemia 11B
Names
B-cell CLL/lymphoma 11B
B-cell lymphoma/leukaemia 11B
COUP-TF-interacting protein 2
mRit1
radiation-induced tumor suppressor gene 1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079883.1NP_001073352.1  B-cell lymphoma/leukemia 11B isoform a

    See identical proteins and their annotated locations for NP_001073352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC119219, AC119921, BM950501, BQ442983, CV563304
    Consensus CDS
    CCDS36553.1
    UniProtKB/Swiss-Prot
    Q99PV8
    Related
    ENSMUSP00000068258.5, ENSMUST00000066060.11
    Conserved Domains (3) summary
    sd00017
    Location:788808
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:787808
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:800825
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001286343.1NP_001273272.1  B-cell lymphoma/leukemia 11B isoform c

    See identical proteins and their annotated locations for NP_001273272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal coding exons but maintains the reading frame, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC119219, AC119921
    Consensus CDS
    CCDS70419.1
    UniProtKB/Swiss-Prot
    Q99PV8
    UniProtKB/TrEMBL
    A0A0R4J1E1
    Related
    ENSMUSP00000105513.2, ENSMUST00000109887.8
    Conserved Domains (3) summary
    sd00017
    Location:594614
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:593614
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:606631
    zf-H2C2_2; Zinc-finger double domain
  3. NM_021399.2NP_067374.2  B-cell lymphoma/leukemia 11B isoform b

    See identical proteins and their annotated locations for NP_067374.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC119219, AC119921, BQ745012, CV563304
    Consensus CDS
    CCDS36552.1
    UniProtKB/Swiss-Prot
    Q99PV8
    Related
    ENSMUSP00000105517.3, ENSMUST00000109891.3
    Conserved Domains (4) summary
    sd00017
    Location:716736
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:356376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:715736
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    107876662..107970404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516111.4XP_006516174.1  B-cell lymphoma/leukemia 11B isoform X4

    Conserved Domains (4) summary
    sd00017
    Location:784804
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:424444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:783804
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:796821
    zf-H2C2_2; Zinc-finger double domain
  2. XM_036157546.1XP_036013439.1  B-cell lymphoma/leukemia 11B isoform X5

    Conserved Domains (4) summary
    sd00017
    Location:783803
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:782803
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:795820
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011244153.3XP_011242455.1  B-cell lymphoma/leukemia 11B isoform X3

    Conserved Domains (4) summary
    sd00017
    Location:787807
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:427447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:786807
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:799824
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006516114.4XP_006516177.1  B-cell lymphoma/leukemia 11B isoform X9

    Conserved Domains (4) summary
    sd00017
    Location:715735
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:355375
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:714735
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:727752
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017315145.3XP_017170634.1  B-cell lymphoma/leukemia 11B isoform X10

    Conserved Domains (4) summary
    sd00017
    Location:670690
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:310330
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669690
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:682707
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017315144.3XP_017170633.1  B-cell lymphoma/leukemia 11B isoform X10

    Conserved Domains (4) summary
    sd00017
    Location:670690
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:310330
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669690
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:682707
    zf-H2C2_2; Zinc-finger double domain
  7. XM_036157548.1XP_036013441.1  B-cell lymphoma/leukemia 11B isoform X8

    Conserved Domains (4) summary
    sd00017
    Location:738758
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:378398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:737758
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:750775
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017315143.3XP_017170632.1  B-cell lymphoma/leukemia 11B isoform X7

    Conserved Domains (4) summary
    sd00017
    Location:742762
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:741762
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:754779
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006516110.5XP_006516173.1  B-cell lymphoma/leukemia 11B isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:468488
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:827848
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:840865
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011244152.4XP_011242454.1  B-cell lymphoma/leukemia 11B isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:832852
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:831852
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:844869
    zf-H2C2_2; Zinc-finger double domain
  11. XM_006516113.5XP_006516176.1  B-cell lymphoma/leukemia 11B isoform X6

    Conserved Domains (4) summary
    sd00017
    Location:760780
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:400420
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:759780
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:772797
    zf-H2C2_2; Zinc-finger double domain
  12. XM_036157549.1XP_036013442.1  B-cell lymphoma/leukemia 11B isoform X8

    Conserved Domains (4) summary
    sd00017
    Location:738758
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:378398
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:737758
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:750775
    zf-H2C2_2; Zinc-finger double domain
  13. XM_036157547.1XP_036013440.1  B-cell lymphoma/leukemia 11B isoform X7

    Conserved Domains (4) summary
    sd00017
    Location:742762
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:741762
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:754779
    zf-H2C2_2; Zinc-finger double domain
  14. XM_006516116.4XP_006516179.1  B-cell lymphoma/leukemia 11B isoform X12

    Conserved Domains (4) summary
    sd00017
    Location:608628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:607628
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:620645
    zf-H2C2_2; Zinc-finger double domain
  15. XM_006516115.4XP_006516178.1  B-cell lymphoma/leukemia 11B isoform X11

    Conserved Domains (4) summary
    sd00017
    Location:657677
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:297317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:656677
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:669694
    zf-H2C2_2; Zinc-finger double domain
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