U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rsad2 radical S-adenosyl methionine domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 58185, updated on 11-Apr-2024

Summary

Official Symbol
Rsad2provided by MGI
Official Full Name
radical S-adenosyl methionine domain containing 2provided by MGI
Primary source
MGI:MGI:1929628
See related
Ensembl:ENSMUSG00000020641 AllianceGenome:MGI:1929628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAND; Vig1; cig5; 2510004L01Rik
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and protein self-association. Involved in several processes, including negative regulation of viral genome replication; positive regulation of T-helper 2 cell cytokine production; and positive regulation of toll-like receptor signaling pathway. Located in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 29.0), spleen adult (RPKM 9.1) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
12 A2; 12 9.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (26492742..26506451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (26442743..26456452, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 144A Neighboring gene RIKEN cDNA 4930549C15 gene Neighboring gene STARR-seq mESC enhancer starr_31787 Neighboring gene microRNA 6538 Neighboring gene cytidine/uridine monophosphate kinase 2 Neighboring gene predicted gene, 46344

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in CD4-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
Names
VHSV-induced-like protein
radical S-adenosyl methionine domain-containing protein 2
viperin
viral hemorrhagic septicemia virus (VHSV)-induced gene 1
virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021384.4NP_067359.2  S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

    See identical proteins and their annotated locations for NP_067359.2

    Status: VALIDATED

    Source sequence(s)
    AK151476, AK153234, CK623585
    Consensus CDS
    CCDS25848.1
    UniProtKB/Swiss-Prot
    Q3U5I6, Q3U5T4, Q3U622, Q3U627, Q3U7I6, Q3U7M1, Q3U8F4, Q3U8U7, Q3U941, Q3U977, Q3U9E1, Q3U9J0, Q3U9J3, Q3UBW6, Q3UC07, Q3UDI0, Q6PEU4, Q8CBB9, Q8VHM2, Q9JHD4
    Related
    ENSMUSP00000020970.8, ENSMUST00000020970.10
    Conserved Domains (2) summary
    cd01335
    Location:79283
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR04278
    Location:13362
    viperin; antiviral radical SAM protein viperin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    26492742..26506451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)