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NEUROD4 neuronal differentiation 4 [ Homo sapiens (human) ]

Gene ID: 58158, updated on 13-Mar-2020

Summary

Official Symbol
NEUROD4provided by HGNC
Official Full Name
neuronal differentiation 4provided by HGNC
Primary source
HGNC:HGNC:13802
See related
Ensembl:ENSG00000123307 MIM:611635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATH3; ATH-3; Atoh3; MATH3; MATH-3; bHLHa4
Expression
Biased expression in adrenal (RPKM 1.3), brain (RPKM 0.2) and 1 other tissue See more
Orthologs

Genomic context

See NEUROD4 in Genome Data Viewer
Location:
12q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (55019974..55030017)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (55413729..55423801)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene thymocyte expressed, positive selection associated 1 Neighboring gene uncharacterized LOC107984515 Neighboring gene uncharacterized LOC101927484 Neighboring gene heat shock transcription factor 2 pseudogene Neighboring gene olfactory receptor family 9 subfamily K member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
amacrine cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
neurogenic differentiation factor 4
Names
class A basic helix-loop-helix protein 4
neurogenic differentiation 4
protein atonal homolog 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021191.3NP_067014.2  neurogenic differentiation factor 4

    See identical proteins and their annotated locations for NP_067014.2

    Status: VALIDATED

    Source sequence(s)
    BC040961, BM683125, DA417566, DA768001
    Consensus CDS
    CCDS8886.1
    UniProtKB/Swiss-Prot
    Q9HD90
    UniProtKB/TrEMBL
    Q8IW56
    Related
    ENSP00000242994.3, ENST00000242994.4
    Conserved Domains (2) summary
    cd00083
    Location:88144
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam12533
    Location:146264
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    55019974..55030017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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