Format

Send to:

Choose Destination

NGB neuroglobin [ Homo sapiens (human) ]

Gene ID: 58157, updated on 3-Jun-2018
Official Symbol
NGBprovided by HGNC
Official Full Name
neuroglobinprovided by HGNC
Primary source
HGNC:HGNC:14077
See related
Ensembl:ENSG00000165553 MIM:605304; Vega:OTTHUMG00000171558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 4.2), brain (RPKM 1.8) and 3 other tissues See more
Orthologs
See NGB in Genome Data Viewer
Location:
14q24.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (77265491..77271312, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77731834..77737655, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 204 member D, pseudogene Neighboring gene transmembrane protein 63C Neighboring gene microRNA 1260a Neighboring gene protein O-mannosyltransferase 2 Neighboring gene glutathione S-transferase zeta 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxygen binding IEA
Inferred from Electronic Annotation
more info
 
oxygen carrier activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
oxygen transport NAS
Non-traceable Author Statement
more info
PubMed 
oxygen transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021257.3NP_067080.1  neuroglobin

    See identical proteins and their annotated locations for NP_067080.1

    Status: REVIEWED

    Source sequence(s)
    AF422797, BC032509
    Consensus CDS
    CCDS9856.1
    UniProtKB/Swiss-Prot
    Q9NPG2
    UniProtKB/TrEMBL
    A0M8W9
    Related
    ENSP00000298352.4, OTTHUMP00000246479, ENST00000298352.4, OTTHUMT00000414194
    Conserved Domains (1) summary
    cd08920
    Location:1148
    Ngb; Neuroglobins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    77265491..77271312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center