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hey2 hes-related family bHLH transcription factor with YRPW motif 2 [ Danio rerio (zebrafish) ]

Gene ID: 58146, updated on 8-Aug-2021

Summary

Official Symbol
hey2provided by ZNC
Official Full Name
hes-related family bHLH transcription factor with YRPW motif 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-000526-1
See related
Ensembl:ENSDARG00000013441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
g; Her; grl; grid; zgc:136746
Orthologs
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Genomic context

See hey2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (39588815..39596338, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (39686180..39693703, complement)
103 previous assembly Zv9 (GCF_000002035.4) 20 NC_007131.5 (39614524..39622047, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member D3 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene HD domain containing 2 Neighboring gene tpd52 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Clone Names

  • MGC136746, MGC194026, MGC194033

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Notch signaling pathway involved in arterial endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within artery development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circulatory system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dorsal aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hairy/enhancer-of-split related with YRPW motif protein 2
Names
Herp2
gridlock
hairy/enhancer-of-split related with YRPW motif 2
protein gridlock

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131622.2NP_571697.2  hairy/enhancer-of-split related with YRPW motif protein 2

    See identical proteins and their annotated locations for NP_571697.2

    Status: VALIDATED

    Source sequence(s)
    AF237948, BC114263
    UniProtKB/Swiss-Prot
    Q9I9L0
    Related
    ENSDARP00000002357.2, ENSDART00000023531.5
    Conserved Domains (2) summary
    cd00083
    Location:49105
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07527
    Location:125162
    Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    39588815..39596338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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