U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

bmpr1aa bone morphogenetic protein receptor, type IAa [ Danio rerio (zebrafish) ]

Gene ID: 58145, updated on 9-Sep-2025
Official Symbol
bmpr1aaprovided by ZNC
Official Full Name
bone morphogenetic protein receptor, type IAaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000502-1
See related
Ensembl:ENSDARG00000019728 AllianceGenome:ZFIN:ZDB-GENE-000502-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
BR1a; alk3; alk3tr; bmpr1a; BMPR-IA; zgc:136731
Summary
Predicted to enable transforming growth factor beta receptor activity, type I. Acts upstream of or within with a positive effect on SMAD protein signal transduction. Acts upstream of or within BMP signaling pathway; circulatory system development; and dorsal/ventral pattern formation. Part of BMP receptor complex. Is expressed in several structures, including blastoderm; digestive system; germ ring; ovarian follicle; and posterior cardinal vein. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See bmpr1aa in Genome Data Viewer
Location:
chromosome: 13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 13 NC_133188.1 (25703321..25767330)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 13 NC_007124.7 (22555791..22619802)

Chromosome 13 - NC_133188.1Genomic Context describing neighboring genes Neighboring gene opsin 4a (melanopsin) Neighboring gene uncharacterized LOC141377179 Neighboring gene LIM domain binding 3a Neighboring gene uncharacterized LOC110438975 Neighboring gene multimerin 2a Neighboring gene zgc:193505 Neighboring gene synuclein, gamma a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A. Demal TJ, et al. Sci Rep, 2019 Feb 27. PMID 30814609, Free PMC Article
  2. Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule. Wu KM, et al. J Biomed Sci, 2006 May. PMID 16456708
  3. A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one. Christian J. Proc Natl Acad Sci U S A, 2021 May 11. PMID 33893177, Free PMC Article
  4. BMP- and neuropilin 1-mediated motor axon navigation relies on spastin alternative translation. Jardin N, et al. Development, 2018 Sep 12. PMID 30082270, Free PMC Article
  5. Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1(R206H) -Specific Human Cellular and Zebrafish Models. Wentworth KL, et al. J Bone Miner Res, 2022 Nov. PMID 36153796, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
    Title: A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
  2. BMP heterodimers signal via distinct type I receptor class functions.
    Title: BMP heterodimers signal via distinct type I receptor class functions.
  3. Data show that BMP signalling controls venous identity via the bone morphogenetic protein receptor type-1A receptor(ALK3/BMPR1A).
    Title: Venous identity requires BMP signalling through ALK3.
  4. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.
    Title: Alk3/Alk3b and Smad5 mediate BMP signaling during lymphatic development in zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC136731

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_positive_effect SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within_positive_effect SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac cell fate specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of heart left/right asymmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic heart tube left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within left/right pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymph vessel development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of BMP receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
bone morphogenetic protein receptor, type IAa
Names
alk3a
bone morphogenetic protein receptor, type 1a
bone morphogenetic protein receptor, type 1aa
NP_571696.2
XP_005156936.1
XP_021336337.1
XP_021336340.1
XP_073776031.1
XP_073776032.1
XP_073776033.1
XP_073776034.1
XP_073776035.1
XP_073776036.1
XP_073776037.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131621.4 → NP_571696.2  bone morphogenetic protein receptor, type IAa precursor

    See identical proteins and their annotated locations for NP_571696.2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000013
    UniProtKB/TrEMBL
    A0A8M1PCF6, Q1RLX1
    Related
    ENSDARP00000015287.7, ENSDART00000026768.9
    Conserved Domains (3) summary
    pfam01064
    Location:59 → 134
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:200 → 227
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl21453
    Location:233 → 519
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133188.1 Reference GRCz12tu Primary Assembly

    Range
    25703321..25767330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073919931.1 → XP_073776032.1  bone morphogenetic protein receptor, type IAa isoform X1

    UniProtKB/TrEMBL
    A0A8M1PCF6, Q1RLX1

  2. XM_073919934.1 → XP_073776035.1  bone morphogenetic protein receptor, type IAa isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFK7, B3DJG0

  3. XM_005156879.6 → XP_005156936.1  bone morphogenetic protein receptor, type IAa isoform X2

    See identical proteins and their annotated locations for XP_005156936.1

    UniProtKB/TrEMBL
    A0A8M9QFK7, B3DJG0
    Related
    ENSDARP00000152766.1
    Conserved Domains (3) summary
    pfam01064
    Location:58 → 133
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:199 → 226
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl21453
    Location:232 → 518
    PKc_like; Protein Kinases, catalytic domain

  4. XM_073919930.1 → XP_073776031.1  bone morphogenetic protein receptor, type IAa isoform X1

    UniProtKB/TrEMBL
    A0A8M1PCF6, Q1RLX1

  5. XM_073919935.1 → XP_073776036.1  bone morphogenetic protein receptor, type IAa isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFK7, B3DJG0

  6. XM_073919936.1 → XP_073776037.1  bone morphogenetic protein receptor, type IAa isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFK7, B3DJG0

  7. XM_073919932.1 → XP_073776033.1  bone morphogenetic protein receptor, type IAa isoform X1

    UniProtKB/TrEMBL
    A0A8M1PCF6, Q1RLX1

  8. XM_021480665.3 → XP_021336340.1  bone morphogenetic protein receptor, type IAa isoform X3

    UniProtKB/TrEMBL
    A0A8M9QNI7
    Conserved Domains (2) summary
    pfam08515
    Location:100 → 127
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl21453
    Location:133 → 419
    PKc_like; Protein Kinases, catalytic domain

  9. XM_021480662.2 → XP_021336337.1  bone morphogenetic protein receptor, type IAa isoform X1

    UniProtKB/TrEMBL
    A0A8M1PCF6, Q1RLX1
    Conserved Domains (3) summary
    pfam01064
    Location:59 → 134
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:200 → 227
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
    cl21453
    Location:233 → 519
    PKc_like; Protein Kinases, catalytic domain

  10. XM_073919933.1 → XP_073776034.1  bone morphogenetic protein receptor, type IAa isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFK7, B3DJG0
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous