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PURB purine rich element binding protein B [ Homo sapiens (human) ]

Gene ID: 5814, updated on 9-Dec-2024

Summary

Official Symbol
PURBprovided by HGNC
Official Full Name
purine rich element binding protein Bprovided by HGNC
Primary source
HGNC:HGNC:9702
See related
Ensembl:ENSG00000146676 MIM:608887; AllianceGenome:HGNC:9702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PURBETA
Summary
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See PURB in Genome Data Viewer
Location:
7p13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44876299..44885530, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45036709..45045943, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44915898..44925129, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44887269-44887826 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44887827-44888385 Neighboring gene H2AZ2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 12861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44924201-44925160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25957 Neighboring gene microRNA 4657 Neighboring gene uncharacterized LOC105375262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951201-44951702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951703-44952202 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, purine-rich element binding protein B (PURB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PURB is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126784, MGC126786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA binding HDA PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SMAD binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA regulatory element binding translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables purine-rich negative regulatory element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of myeloid cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcriptional regulator protein Pur-beta
Names
transcriptional activator protein Pur-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033224.5NP_150093.1  transcriptional regulator protein Pur-beta

    See identical proteins and their annotated locations for NP_150093.1

    Status: REVIEWED

    Source sequence(s)
    AC004854
    Consensus CDS
    CCDS5499.1
    UniProtKB/Swiss-Prot
    A4D2L7, Q96QR8
    Related
    ENSP00000379051.2, ENST00000395699.5
    Conserved Domains (1) summary
    pfam04845
    Location:31279
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44876299..44885530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    45036709..45045943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)