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PURB purine rich element binding protein B [ Homo sapiens (human) ]

Gene ID: 5814, updated on 21-Dec-2019

Summary

Official Symbol
PURBprovided by HGNC
Official Full Name
purine rich element binding protein Bprovided by HGNC
Primary source
HGNC:HGNC:9702
See related
Ensembl:ENSG00000146676 MIM:608887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PURBETA
Summary
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See PURB in Genome Data Viewer
Location:
7p13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44876299..44885530, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44915892..44924960, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 2 Neighboring gene long intergenic non-protein coding RNA 1952 Neighboring gene microRNA 4657 Neighboring gene uncharacterized LOC105375262 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, purine-rich element binding protein B (PURB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PURB is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126784, MGC126786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
purine-rich negative regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of myeloid cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
DNA replication factor A complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional activator protein Pur-beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033224.5NP_150093.1  transcriptional activator protein Pur-beta

    See identical proteins and their annotated locations for NP_150093.1

    Status: REVIEWED

    Source sequence(s)
    AC004854
    Consensus CDS
    CCDS5499.1
    UniProtKB/Swiss-Prot
    Q96QR8
    Related
    ENSP00000379051.2, ENST00000395699.5
    Conserved Domains (1) summary
    pfam04845
    Location:31279
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44876299..44885530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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