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fgfr3 fibroblast growth factor receptor 3 [ Danio rerio (zebrafish) ]

Gene ID: 58129, updated on 8-Aug-2021

Summary

Official Symbol
fgfr3provided by ZNC
Official Full Name
fibroblast growth factor receptor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-000816-1
See related
Ensembl:ENSDARG00000004782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Z-FGFR; fc27h01; sb:eu56; sb:eu563; wu:fc27h01
Orthologs
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Genomic context

See fgfr3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (13213566..13294982, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (13081091..13163841, complement)
103 previous assembly Zv9 (GCF_000002035.4) 13 NC_007124.5 (13087812..13155627, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene uncharacterized LOC108191973 Neighboring gene uncharacterized LOC108191974

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor receptor 3
NP_571681.2
XP_009305459.1
XP_009305463.1
XP_017214284.1
XP_021336328.1
XP_021336329.1
XP_021336330.1
XP_021336331.1
XP_021336332.1
XP_021336333.1
XP_021336334.1
XP_021336335.1
XP_021336336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131606.2NP_571681.2  fibroblast growth factor receptor 3

    Status: VALIDATED

    Source sequence(s)
    CR556722, CR559942, CU694230, LO018146
    UniProtKB/TrEMBL
    F1QHL9
    Related
    ENSDARP00000011898.9, ENSDART00000013534.9
    Conserved Domains (7) summary
    cd04974
    Location:280369
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:173257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:466799
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:183257
    IG; Immunoglobulin
    smart00410
    Location:272368
    IG_like; Immunoglobulin like
    pfam07714
    Location:479754
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    13213566..13294982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480656.1XP_021336331.1  fibroblast growth factor receptor 3 isoform X6

    Conserved Domains (4) summary
    cd05857
    Location:172256
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:467800
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
    cd04974
    Location:279366
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
  2. XM_009307184.3XP_009305459.1  fibroblast growth factor receptor 3 isoform X5

    Conserved Domains (7) summary
    cd04974
    Location:280367
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:173257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:467800
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:183257
    IG; Immunoglobulin
    smart00410
    Location:272367
    IG_like; Immunoglobulin like
    pfam07714
    Location:480755
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_021480654.1XP_021336329.1  fibroblast growth factor receptor 3 isoform X2

    Conserved Domains (4) summary
    cd05857
    Location:173257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:468801
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
    cd04974
    Location:280367
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
  4. XM_021480658.1XP_021336333.1  fibroblast growth factor receptor 3 isoform X9

    Conserved Domains (4) summary
    cd05857
    Location:168252
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:275364
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:463796
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
  5. XM_021480657.1XP_021336332.1  fibroblast growth factor receptor 3 isoform X7

    Conserved Domains (4) summary
    cd05857
    Location:169253
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:276365
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:464797
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
  6. XM_021480655.1XP_021336330.1  fibroblast growth factor receptor 3 isoform X4

    Conserved Domains (4) summary
    cd05857
    Location:172256
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:279368
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:467800
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
  7. XM_021480661.1XP_021336336.1  fibroblast growth factor receptor 3 isoform X12

    Conserved Domains (3) summary
    cd05857
    Location:83167
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:190279
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:378711
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
  8. XM_021480660.1XP_021336335.1  fibroblast growth factor receptor 3 isoform X11

    Conserved Domains (3) summary
    cd05857
    Location:84168
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:191280
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:379712
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
  9. XM_021480659.1XP_021336334.1  fibroblast growth factor receptor 3 isoform X10

    Conserved Domains (4) summary
    cd05857
    Location:168252
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:275364
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:462795
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
  10. XM_009307188.3XP_009305463.1  fibroblast growth factor receptor 3 isoform X8

    Conserved Domains (7) summary
    cd04974
    Location:276365
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:169253
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:463796
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:179253
    IG; Immunoglobulin
    smart00410
    Location:268364
    IG_like; Immunoglobulin like
    pfam07714
    Location:476751
    Pkinase_Tyr; Protein tyrosine kinase
  11. XM_017358795.2XP_017214284.1  fibroblast growth factor receptor 3 isoform X3

  12. XM_021480653.1XP_021336328.1  fibroblast growth factor receptor 3 isoform X1

    Conserved Domains (4) summary
    cd05857
    Location:173257
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:280369
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:468801
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:67121
    IGc2; Immunoglobulin C-2 Type

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395307.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    270317..294997 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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