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runx3 RUNX family transcription factor 3 [ Danio rerio (zebrafish) ]

Gene ID: 58127, updated on 22-Nov-2020

Summary

Official Symbol
runx3provided by ZNC
Official Full Name
RUNX family transcription factor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-000605-2
See related
Ensembl:ENSDARG00000052826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
run; runxb
Orthologs

Genomic context

See runx3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (45092766..45155284, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (44955862..45018380, complement)
103 previous assembly Zv9 (GCF_000002035.4) 13 NC_007124.5 (45712363..45775791, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene KH domain containing, RNA binding, signal transduction associated 1a Neighboring gene calcineurin-like EF-hand protein 1 Neighboring gene uncharacterized LOC108191951 Neighboring gene zinc finger-like gene 1g

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemopoiesis IEP
Inferred from Expression Pattern
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
runt-related transcription factor 3
Names
runt-related transcription factor b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362344.1NP_001349273.1  runt-related transcription factor 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CABZ01078998, CABZ01083960, CT025744
    Conserved Domains (2) summary
    pfam00853
    Location:69190
    Runt; Runt domain
    pfam08504
    Location:334438
    RunxI; Runx inhibition domain
  2. NM_131604.3NP_571679.2  runt-related transcription factor 3 isoform 2

    See identical proteins and their annotated locations for NP_571679.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CABZ01083960, CT025744
    UniProtKB/TrEMBL
    Q9DEA0
    Related
    ENSDARP00000136974.1, ENSDART00000161144.2
    Conserved Domains (2) summary
    pfam00853
    Location:55176
    Runt; Runt domain
    pfam08504
    Location:320424
    RunxI; Runx inhibition domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    45092766..45155284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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