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runx1 RUNX family transcription factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 58126, updated on 20-Nov-2021

Summary

Official Symbol
runx1provided by ZNC
Official Full Name
RUNX family transcription factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-000605-1
See related
Ensembl:ENSDARG00000087646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
runxa
Orthologs
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Genomic context

See runx1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (1361974..1402588, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (1241703..1253991, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003334029.1 (7866..22130)
103 previous assembly Zv9 (GCF_000002035.4) 1 NC_007112.5 (1063376..1077640) , (1088741..1101029, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101886071 Neighboring gene downstream neighbor of SON Neighboring gene microRNA 459 Neighboring gene urotensin II-related peptide

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial to hematopoietic transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neutrophil differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of connective tissue replacement IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neutrophil differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of plasminogen activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
runt-related transcription factor 1
Names
aml1
runt-related transcription factor a
runx1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131603.3NP_571678.1  runt-related transcription factor 1

    See identical proteins and their annotated locations for NP_571678.1

    Status: VALIDATED

    Source sequence(s)
    CZQB01066254, CZQB01066256, LO018592
    UniProtKB/TrEMBL
    Q9DGB8
    Conserved Domains (3) summary
    pfam00853
    Location:63184
    Runt; Runt domain
    pfam08504
    Location:359451
    RunxI; Runx inhibition domain
    cl26464
    Location:160426
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    1361974..1402588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475829.1XP_021331504.1  runt-related transcription factor 1 isoform X1

    Related
    ENSDARP00000112019.3, ENSDART00000130697.3
    Conserved Domains (3) summary
    pfam00853
    Location:63184
    Runt; Runt domain
    pfam08504
    Location:359451
    RunxI; Runx inhibition domain
    cl26464
    Location:160426
    Atrophin-1; Atrophin-1 family
  2. XM_021475832.1XP_021331507.1  runt-related transcription factor 1 isoform X2

    Conserved Domains (2) summary
    pfam00853
    Location:63182
    Runt; Runt domain
    pfam08504
    Location:303395
    RunxI; Runx inhibition domain
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