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smad3a SMAD family member 3a [ Danio rerio (zebrafish) ]

Gene ID: 58092, updated on 22-Nov-2020

Summary

Official Symbol
smad3aprovided by ZNC
Official Full Name
SMAD family member 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000509-3
See related
Ensembl:ENSDARG00000036096
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sma; madh; madh3; smad3; madh3a; wu:fa99e0; wu:fa99e03
Orthologs

Genomic context

See smad3a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (34106111..34149234, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (33834961..33878084, complement)
103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (35450168..35493994, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene SKI family transcriptional corepressor 1a Neighboring gene mitogen-activated protein kinase kinase 5 Neighboring gene SMAD family member 6a Neighboring gene crystallin beta gamma X

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
primitive hemopoiesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mothers against decapentaplegic homolog 3a
Names
MAD homolog 3
MAD homolog 3a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131571.2NP_571646.1  mothers against decapentaplegic homolog 3a

    See identical proteins and their annotated locations for NP_571646.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129150
    UniProtKB/TrEMBL
    Q8AY15
    Related
    ENSDARP00000045373.5, ENSDART00000045374.8
    Conserved Domains (2) summary
    cd10491
    Location:7131
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:224414
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    34106111..34149234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394698.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    71432..114903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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