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PTX3 pentraxin 3 [ Homo sapiens (human) ]

Gene ID: 5806, updated on 10-Jun-2018
Official Symbol
PTX3provided by HGNC
Official Full Name
pentraxin 3provided by HGNC
Primary source
HGNC:HGNC:9692
See related
Ensembl:ENSG00000163661 MIM:602492; Vega:OTTHUMG00000158750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG-14; TNFAIP5
Summary
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
Expression
Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues See more
Orthologs
See PTX3 in Genome Data Viewer
Location:
3q25.32
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (157436791..157443628)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (157154580..157161417)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928236 Neighboring gene poly(rC) binding protein 1 pseudogene Neighboring gene uncharacterized LOC105374179 Neighboring gene ventricular zone expressed PH domain containing 1 Neighboring gene PQ loop repeat containing 2 like Neighboring gene VISTA enhancer hs638

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Lung fibrosis, organism-specific biosystem (from WikiPathways)
    Lung fibrosis, organism-specific biosystemLung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
(1->3)-beta-D-glucan binding IEA
Inferred from Electronic Annotation
more info
 
complement component C1q binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement component C1q binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation by host of viral process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
opsonization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
response to yeast IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
pentraxin-related protein PTX3
Names
TNF alpha-induced protein 5
long pentraxin 3
tumor necrosis factor alpha-induced protein 5
tumor necrosis factor-inducible gene 14 protein
tumor necrosis factor-inducible protein TSG-14

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051000.1 RefSeqGene

    Range
    5001..11838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002852.3NP_002843.2  pentraxin-related protein PTX3 precursor

    See identical proteins and their annotated locations for NP_002843.2

    Status: REVIEWED

    Source sequence(s)
    BC039733, BQ010272, DA716533
    Consensus CDS
    CCDS3180.1
    UniProtKB/Swiss-Prot
    P26022
    Related
    ENSP00000295927.3, OTTHUMP00000213379, ENST00000295927.3, OTTHUMT00000352028
    Conserved Domains (2) summary
    smart00159
    Location:175381
    PTX; Pentraxin / C-reactive protein / pentaxin family
    cl23844
    Location:81167
    Ble; Predicted trehalose synthase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    157436791..157443628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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