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PTPRZ1 protein tyrosine phosphatase receptor type Z1 [ Homo sapiens (human) ]

Gene ID: 5803, updated on 21-Dec-2019

Summary

Official Symbol
PTPRZ1provided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Z1provided by HGNC
Primary source
HGNC:HGNC:9685
See related
Ensembl:ENSG00000106278 MIM:176891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPZ; HPTPZ; PTP18; PTPRZ; RPTPB; HPTPzeta; PTP-ZETA; RPTPbeta; phosphacan; R-PTP-zeta-2
Summary
This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Expression
Biased expression in brain (RPKM 103.2) and skin (RPKM 10.8) See more
Orthologs

Genomic context

See PTPRZ1 in Genome Data Viewer
Location:
7q31.32
Exon count:
31
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (121873161..122062036)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (121513159..121702090)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 277 Neighboring gene polyribonucleotide nucleotidyltransferase 1 pseudogene 2 Neighboring gene RNA, U7 small nuclear 154 pseudogene Neighboring gene aminoadipate-semialdehyde synthase Neighboring gene tetratricopeptide repeat domain 14 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of oligodendrocyte progenitor proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
perineuronal net IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase zeta
Names
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
protein tyrosine phosphatase, receptor-type, zeta polypeptide 1
protein-tyrosine phosphatase receptor type Z polypeptide 2
receptor-type tyrosine phosphatase beta/zeta
NP_001193767.1
NP_001193768.1
NP_001356324.1
NP_001356325.1
NP_002842.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023266.1 RefSeqGene

    Range
    5057..193932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1387

mRNA and Protein(s)

  1. NM_001206838.2NP_001193767.1  receptor-type tyrosine-protein phosphatase zeta isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193767.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK294062, DA454064, M93426, U88967
    UniProtKB/Swiss-Prot
    P23471
    UniProtKB/TrEMBL
    B4DFE7
    Related
    ENSP00000499073.1, ENST00000651065.1
    Conserved Domains (4) summary
    smart00194
    Location:8561131
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8921131
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313401
    fn3; Fibronectin type III domain
  2. NM_001206839.2NP_001193768.1  receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame donor splice site at an internal coding exon, and is lacking another in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    BC131736, DA454064, M93426, U88967
    Consensus CDS
    CCDS56505.1
    UniProtKB/Swiss-Prot
    P23471
    Related
    ENSP00000410000.1, ENST00000449182.1
    Conserved Domains (4) summary
    smart00194
    Location:8561124
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8851124
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313401
    fn3; Fibronectin type III domain
  3. NM_001369395.1NP_001356324.1  receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC006020, AC006353, AC073095
    Related
    ENSP00000499137.1, ENST00000652298.1
    Conserved Domains (5) summary
    cd03122
    Location:45298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam07263
    Location:14501567
    DMP1; Dentin matrix protein 1 (DMP1)
    pfam00041
    Location:313395
    fn3; Fibronectin type III domain
    cd17669
    Location:20702273
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    cl28904
    Location:17171987
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. NM_001369396.1NP_001356325.1  receptor-type tyrosine-protein phosphatase zeta isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006020, AC006353, AC073095
    Conserved Domains (5) summary
    cd03122
    Location:31284
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam07263
    Location:14361553
    DMP1; Dentin matrix protein 1 (DMP1)
    pfam00041
    Location:299381
    fn3; Fibronectin type III domain
    cd17669
    Location:20632266
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    cl28904
    Location:17031980
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. NM_002851.3NP_002842.2  receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

    See identical proteins and their annotated locations for NP_002842.2

    Status: REVIEWED

    Source sequence(s)
    CX868991, CX872418, DA101746, DA454064, M93426, U88967
    Consensus CDS
    CCDS34740.1
    UniProtKB/Swiss-Prot
    P23471
    Related
    ENSP00000377047.2, ENST00000393386.7
    Conserved Domains (6) summary
    smart00194
    Location:17161991
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:17521991
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313401
    fn3; Fibronectin type III domain
    pfam07777
    Location:684763
    MFMR; G-box binding protein MFMR
    pfam17061
    Location:10891255
    PARM; PARM

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    121873161..122062036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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